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The authors aimed to investigate the influence of <jats:italic>FTO<\/jats:italic> variation on frontostriatal appetite circuits in early life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were drawn from RESONANCE, a longitudinal study of early brain development. Growth trajectories of nucleus accumbens and frontal lobe volumes, as well as total gray matter and white matter volume, by risk allele (AA) carrier status on <jats:italic>FTO<\/jats:italic> single\u2010nucleotide polymorphism rs9939609 were examined in 228 children (102\u2009female, 126\u2009male) using magnetic resonance imaging assessments obtained from infancy through middle childhood. The authors fit functional concurrent regression models with brain volume outcomes over age as functional responses, and <jats:italic>FTO<\/jats:italic> genotype, sex, BMI <jats:italic>z<\/jats:italic> score, and maternal education were included as predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bootstrap pointwise 95% CI for regression coefficient functions in the functional concurrent regression models showed that the AA group versus the group with no risk allele (TT) had greater nucleus accumbens volume (adjusted for total brain volume) in the interval of 750 to 2250\u2009days (2\u20136\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that common genetic risk for obesity is associated with differences in early development of brain reward circuitry and argue for investigating dynamic relationships among genotype, brain, behavior, and weight throughout development.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23926","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T04:29:47Z","timestamp":1697084987000},"page":"156-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp><i>FTO<\/i><\/scp> variation and early frontostriatal brain development in children"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9586-8851","authenticated-orcid":false,"given":"Gita","family":"Thapaliya","sequence":"first","affiliation":[{"name":"Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poorbita","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Statistics University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Jansen","sequence":"additional","affiliation":[{"name":"Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus A.","family":"Naymik","sequence":"additional","affiliation":[{"name":"Neurogenomics Division The Translational Genomics Research Institute (TGen)  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel Marisa Katharina","family":"Bruchhage","sequence":"additional","affiliation":[{"name":"Advanced Baby Imaging Lab Hasbro Children's Hospital, Rhode Island Hospital  Providence Rhode Island USA"},{"name":"Department of Pediatrics Warren Alpert Medical School at Brown University  Providence Rhode Island USA"},{"name":"Department of Psychology, Social Sciences University of Stavanger  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viren","family":"D'Sa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Warren Alpert Medical School at Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Huentelman","sequence":"additional","affiliation":[{"name":"Neurogenomics Division The Translational Genomics Research Institute (TGen)  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace R.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Neurogenomics Division The Translational Genomics Research Institute (TGen)  Phoenix Arizona USA"},{"name":"School of Life Sciences Arizona State University  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Georg","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Statistics University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean C. 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