{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:40:18Z","timestamp":1791826818307,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK121548"],"award-info":[{"award-number":["R01DK121548"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK102619"],"award-info":[{"award-number":["R01DK102619"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2024,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n The adipose tissue\u2013liver axis is a major regulator of the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Retinoic acid signaling plays an important role in development and metabolism. However, little is known about the role of adipose retinoic acid signaling in the development of obesity\u2010associated NAFLD. In this work, the aim was to investigate whether and how retinoic acid receptor alpha (RAR\u03b1) regulated the development of obesity and NAFLD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n RAR\u03b1 expression in adipose tissue of\n db\/db<\/jats:italic>\n or\n ob\/ob<\/jats:italic>\n mice was determined.\n Rar\u03b1<\/jats:italic>\n \n fl\/fl<\/jats:italic>\n <\/jats:sup>\n mice and adipocyte\u2010specific\n Rar\u03b1<\/jats:italic>\n \u2212\/\u2212<\/jats:sup>\n (\n Rar\u03b1<\/jats:italic>\n \n Adi\u2212\/\u2212<\/jats:italic>\n <\/jats:sup>\n ) mice were fed a chow diet for 1\u2009year or high\u2010fat diet (HFD) for 20\u2009weeks. Primary adipocytes and primary hepatocytes were co\u2010cultured. Metabolic regulation and inflammatory response were characterized.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n RAR\u03b1 expression was reduced in adipose tissue of\n db\/db<\/jats:italic>\n or\n ob\/ob<\/jats:italic>\n mice.\n Rar\u03b1<\/jats:italic>\n \n Adi\u2212\/\u2212<\/jats:italic>\n <\/jats:sup>\n mice had increased obesity and steatohepatitis (NASH) when fed a chow diet or HFD. Loss of adipocyte RAR\u03b1 induced lipogenesis and inflammation in adipose tissue and the liver and reduced thermogenesis. In the co\u2010culture studies, loss of RAR\u03b1 in adipocytes induced inflammatory and lipogenic programs in hepatocytes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The data demonstrate that RAR\u03b1 in adipocytes prevents obesity and NASH via inhibiting lipogenesis and inflammation and inducing energy expenditure.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/oby.23929","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T06:07:50Z","timestamp":1698127670000},"page":"120-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Adipocyte retinoic acid receptor \u03b1 prevents obesity and steatohepatitis by regulating energy expenditure and lipogenesis"],"prefix":"10.1002","volume":"32","author":[{"given":"Fathima N.","family":"Cassim Bawa","sequence":"first","affiliation":[{"name":"Department of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Gopoju","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Shiyab","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Mongan","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio 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