{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:14:42Z","timestamp":1791346482528,"version":"4.3.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20 GM144269"],"award-info":[{"award-number":["P20 GM144269"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR071263"],"award-info":[{"award-number":["R01 AR071263"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["F32 DK127693"],"award-info":[{"award-number":["F32 DK127693"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK099611"],"award-info":[{"award-number":["R01 DK099611"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["S10 OD028598"],"award-info":[{"award-number":["S10 OD028598"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The impact of early\u2010life stress on weight\u2010loss maintenance is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mice underwent neonatal maternal separation (NMS) from 0 to 3\u2009weeks and were weaned onto a high\u2010fat sucrose diet (HFSD) from 3 to 20\u2009weeks. Calorie\u2010restricted weight loss on a low\u2010fat sucrose diet (LFSD) occurred over 2\u2009weeks to induce a 20% loss in body weight, which was maintained for 6\u2009weeks. After weight loss, half of the mice received running wheels, and the other half remained sedentary. Mice were then fed ad libitum on an HFSD or LFSD for 10\u2009weeks and were allowed to regain body weight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NMS mice had greater weight regain, total body weight, and adiposity compared with na\u00efve mice. During the first week of refeeding, NMS mice had increased food intake and were in a greater positive energy balance than na\u00efve mice. Female mice were more susceptible to NMS\u2010induced effects, including increases in adiposity. NMS and na\u00efve females were more susceptible to HFSD\u2010induced weight regain. Exercise was beneficial in the first week of regain in male mice, but, long\u2010term, only those on the LFSD benefited from exercise. As expected, HFSD led to greater weight regain than LFSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early\u2010life stress increases weight regain in mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.23931","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T03:48:34Z","timestamp":1703216914000},"page":"131-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exposure to early\u2010life stress impairs weight\u2010loss maintenance success in mice"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0980-6046","authenticated-orcid":false,"given":"Rebecca M.","family":"Foright","sequence":"first","affiliation":[{"name":"Department of Cell Biology &amp; Physiology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara E.","family":"McQuillan","sequence":"additional","affiliation":[{"name":"Department of Cell Biology &amp; Physiology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna M.","family":"Frick","sequence":"additional","affiliation":[{"name":"Department of Cell Biology &amp; Physiology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige M.","family":"Minchella","sequence":"additional","affiliation":[{"name":"Department of Cell Biology &amp; Physiology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittni M.","family":"Levasseur","sequence":"additional","affiliation":[{"name":"Department of Cell Biology &amp; Physiology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Tinoco","sequence":"additional","affiliation":[{"name":"Department of Cell Biology &amp; Physiology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauryn","family":"Birmingham","sequence":"additional","affiliation":[{"name":"Department of Cell Biology &amp; Physiology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneka E.","family":"Blankenship","sequence":"additional","affiliation":[{"name":"Department of Cell Biology &amp; Physiology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Thyfault","sequence":"additional","affiliation":[{"name":"Department of Cell Biology &amp; Physiology University of Kansas Medical Center  Kansas City Kansas USA"},{"name":"Kansas Center Metabolism and Obesity Research  Kansas City Kansas USA"},{"name":"Research Service Kansas City Veterans Affairs Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Christianson","sequence":"additional","affiliation":[{"name":"Department of Cell Biology &amp; Physiology University of Kansas Medical Center  Kansas City Kansas USA"},{"name":"Kansas Center Metabolism and Obesity Research  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21487"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(98)00017-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2007.02.036"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.160"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1554"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(17)30118-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.08.010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2403"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0000000000000049"},{"key":"e_1_2_9_11_1","unstructured":"World Obesity Federation.World Obesity Atlas.2023."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JCN.0000317471.58048.32"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.1.222S"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21538"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00755.2010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2018.01.025"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318213fefb"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2018.07.014"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.11.1343"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-8-49"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00650.2003"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00192.2009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22155"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200212000-00020"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00216.2022"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2020.113000"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.12.022"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0179-18.2019"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2013.00130"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010023\u201002714\u2010y"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2022.809944"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.02.039"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2017.00097"},{"key":"e_1_2_9_34_1","unstructured":"FryarCD CarrollMD AffulJ.Prevalence of overweight obesity and severe obesity among adults aged 20 and over: United States 1960\u20131962 through 2017\u20132018. 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