{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:08:27Z","timestamp":1789686507528,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the efficacy and safety of semaglutide 2.4\u2009mg in people with overweight\/obesity who were also being treated with antidepressants (ADs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Across the Semaglutide Treatment Effect for People with obesity (STEP) 1\u20133 and 5 trials, adults with overweight\/obesity and type 2 diabetes (STEP 2 only) were enrolled. People with severe major depressive disorder within 2\u2009years prior to screening or with a patient health questionnaire\u20109 score\u2009\u226515 at screening were excluded. Participants were categorized into subgroups according to baseline AD status (on\/off ADs) in this post hoc exploratory analysis of the STEP trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 3683 participants randomized, 539 were on ADs at baseline. Mean body weight change from baseline to week 68 was greater for semaglutide versus placebo, regardless of baseline AD use. In STEP 1, for participants on ADs at baseline, mean change from baseline was \u221215.7% with semaglutide versus \u22120.2% with placebo and\u2009\u221214.7% versus \u22122.8% for those not on ADs at baseline. Similar patterns were seen in STEP 2, 3, and 5. The prevalence of adverse events (AEs) was generally similar between semaglutide and placebo in participants on ADs at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In adults with overweight\/obesity, semaglutide provided clinically meaningful weight loss regardless of baseline AD use, with an AE profile consistent with previous studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23946","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T11:22:45Z","timestamp":1700652165000},"page":"273-280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy and safety of semaglutide 2.4\u2009mg according to antidepressant use at baseline: A post hoc subgroup analysis"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-3705","authenticated-orcid":false,"given":"Robert F.","family":"Kushner","sequence":"first","affiliation":[{"name":"Department of Medicine and Medical Education, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Fink\u2010Jensen","sequence":"additional","affiliation":[{"name":"Psychiatric Centre Copenhagen and Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofir","family":"Frenkel","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2015-726X","authenticated-orcid":false,"given":"Barbara","family":"McGowan","sequence":"additional","affiliation":[{"name":"Cleveland Clinic London Hospital Portland Place Outpatient Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Goldman","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Overvad","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0438-4609","authenticated-orcid":false,"given":"Thomas","family":"Wadden","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases8020023"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010018\u20100017\u20105"},{"key":"e_1_2_11_4_1","first-page":"1","article-title":"Depression and obesity in the U.S. adult household population, 2005\u20102010","volume":"167","author":"Pratt LA","year":"2014","journal-title":"NCHS Data Brief"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22209"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg275"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.3650"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101525\u20102820"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245722"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09r05346blu"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010027663"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.3445"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23191"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j603"},{"key":"e_1_2_11_15_1","unstructured":"Wegovy (semaglutide) injection. 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