{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:32:00Z","timestamp":1787509920509,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["K24\u2010HD\u201001464"],"award-info":[{"award-number":["K24\u2010HD\u201001464"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["RO1\u2010HD\u201040787"],"award-info":[{"award-number":["RO1\u2010HD\u201040787"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000938","name":"Robert E. Leet and Clara Guthrie Patterson Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000938","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to examine the hypothesis that abdominal and gluteal adipocyte turnover, lipid dynamics, and fibrogenesis are dysregulated among insulin\u2010resistant (IR) compared with insulin\u2010sensitive (IS) adolescents with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seven IS and seven IR adolescents with obesity participated in a 3\u2010h oral glucose tolerance test and a multi\u2010section magnetic resonance imaging scan of the abdominal region to examine body fat distribution patterns and liver fat content. An 8\u2010week 70% deuterated water (\n                      <jats:sup>2<\/jats:sup>\n                      H\n                      <jats:sub>2<\/jats:sub>\n                      O) labeling protocol examined adipocyte turnover, lipid dynamics, and fibrogenesis in vivo from biopsied abdominal and gluteal fat.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Abdominal and gluteal subcutaneous adipose tissue (SAT) turnover rates of lipid components were similar among IS and IR adolescents with obesity. However, the insoluble collagen (type I, subunit \u03b12) isoform measured from abdominal, but not gluteal, SAT was elevated in IR compared with IS individuals. In addition, abdominal insoluble collagen I\u03b12 was associated with ratios of visceral\u2010to\u2010total (visceral adipose tissue\u2009+\u2009SAT) abdominal fat and whole\u2010body and adipose tissue insulin signaling, and it trended toward a positive association with liver fat content.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Altered extracellular matrix dynamics, but not expandability, potentially decreases abdominal SAT lipid storage capacity, contributing to the pathophysiological pathways linking adipose tissue and whole\u2010body IR with altered ectopic storage of lipids within the liver among IR adolescents with obesity.<\/jats:p>\n                  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