{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:15:20Z","timestamp":1774682120551,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004346","name":"Stiftung Rheinland-Pfalz f\u00fcr Innovation","doi-asserted-by":"publisher","award":["contractAZ961\u2010386261\/733"],"award-info":[{"award-number":["contractAZ961\u2010386261\/733"]}],"id":[{"id":"10.13039\/501100004346","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024099","name":"Philips Medical Systems","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to investigate whether an obesity\u2010related inflammatory protein signature (OIPS) is associated with adverse cardiovascular events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Olink Target 96 Inflammation panel was performed in 6662 participants from the population\u2010based Gutenberg Health Study (GHS). The OIPS was selected by a logistic regression model, and its association with cardiovascular outcomes was evaluated by Cox regression analysis. The GHS\u2010derived OIPS was externally validated in the MyoVasc study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The identified OIPS entailed 21 proteins involved in chemokine activity, tumor necrosis factor (TNF) receptor binding, and growth factor receptor binding. The signature revealed a novel positive association of axis inhibition protein 1 with obesity. The OIPS was associated with increased risk of all\u2010cause and cardiac deaths, major adverse cardiovascular events, and incident coronary artery disease, independent of clinical covariates and established risk instruments. A BMI\u2010stratified analysis confirmed the association of OIPS with increased death in those with obesity and overweight and with increased risk for coronary artery disease in those with obesity. The association of OIPS with increased risk of all\u2010cause and cardiac deaths was validated in the MyoVasc cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The OIPS showed a significant association with adverse clinical outcomes, particularly in those with overweight and obesity, and represents a promising tool for identifying patients at higher risk for worse cardiovascular outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24014","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T03:04:00Z","timestamp":1714100640000},"page":"1198-1209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Obesity\u2010related inflammatory protein signature in cardiovascular clinical outcomes: results from the Gutenberg Health Study"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2155-8030","authenticated-orcid":false,"given":"Marina","family":"Panova\u2010Noeva","sequence":"first","affiliation":[{"name":"Translational Medicine and Clinical Pharmacology Boehringer Ingelheim Pharma GmbH &amp; Co. 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