{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:26:11Z","timestamp":1792034771937,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008568","name":"Norske Kvinners Sanitetsforening","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008568","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The primary objective of this study was to evaluate the effect of a low\u2010carbohydrate diet (LCD) compared with a control diet on pain in female patients with lipedema. The secondary objectives were to compare the impact of the two diets on quality of life (QoL) and investigate potential associations of changes in pain with changes in body weight, body composition, and ketosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult female patients with lipedema and obesity were randomized to either the LCD or control diet (energy prescription: 1200\u2009kcal\/day) for 8\u2009weeks. Body weight and body composition, pain (Brief Pain Inventory measured pain), and QoL (RAND 36\u2010Item Health Survey [RAND\u201036], Impact of Weight on Quality of Life [IWQOL]\u2010Lite, and Lymphoedema Quality of Life [LYMQOL]) were measured at baseline and at postintervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 70 female patients (age, mean\u2009[SD], 47\u2009[11]\u2009years; BMI 37\u2009[5]\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) were included. The LCD group had greater weight loss (\u22122.8\u2009kg; 95% CI: \u22124.1 to \u22121.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and larger reduction in pain now (\u22121.1; 95% CI: \u22121.9 to \u22120.3;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) compared with the control group. No association was found between changes in pain now and weight loss. Both groups experienced improvements in several QoL dimensions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diet\u2010induced weight loss in women with lipedema can improve QoL. An energy\u2010restricted LCD seems to be superior to a standard control diet in reducing pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.24026","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T20:58:35Z","timestamp":1713301115000},"page":"1071-1082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Effect of a low\u2010carbohydrate diet on pain and quality of life in female patients with lipedema: a randomized controlled trial"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2999-0849","authenticated-orcid":false,"given":"Julianne","family":"Lundanes","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Clinic of Surgery Nord\u2010Tr\u00f8ndelag Hospital Trust, Namsos 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