{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:11:24Z","timestamp":1788541884051,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","award":["BJRITO\u2010RDP\u20102024"],"award-info":[{"award-number":["BJRITO\u2010RDP\u20102024"]}],"id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371957"],"award-info":[{"award-number":["82371957"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371956"],"award-info":[{"award-number":["82371956"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We analyzed quantitative computed tomography (CT) and chemical shift\u2013encoded magnetic resonance imaging (MRI) data from a Chinese cohort to investigate the effects of BMI and aging on different adipose tissue (AT) depots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 400 healthy, community\u2010dwelling individuals aged 22 to 83\u2009years, we used MRI to quantify proton density fat fraction (PDFF) of the lumbar spine (L2\u2013L4) bone marrow AT (BMAT), the psoas major and erector spinae (ES) muscles, and the liver. Abdominal total AT, visceral AT (VAT), and subcutaneous AT (SAT) areas were measured at the L2\u2010L3 level using quantitative CT. Partial correlation analysis was used to evaluate the relationship of each AT variable with age and BMI. Multiple linear regression analysis was performed in which each AT variable was evaluated in turn as a function of age and the other five independent AT measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 168 men, 29% had normal BMI (&lt;24.0\u2009kg\/m<jats:sup>2<\/jats:sup>), 47% had overweight (24.0\u201327.9\u2009kg\/m<jats:sup>2<\/jats:sup>), and 24% had obesity (\u2265\u200928.0\u2009kg\/m<jats:sup>2<\/jats:sup>). In the 232 women, the percentages were 46%, 32%, and 22%, respectively. Strong or very strong correlations with BMI were found for total AT, VAT, and SAT in both sexes. BMAT and ES PDFF was strongly correlated with age in women and moderately correlated in men. In both sexes, BMAT PDFF correlated only with age and not with any of the other AT depots. Psoas PDFF correlated only with ES PDFF and not with age or the other AT depots. Liver PDFF correlated with BMI and VAT and weakly with SAT in men. VAT and SAT correlated with age and each other in both sexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Age and BMI are both associated with adiposity, but their effects differ depending on the type of AT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24040","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T04:07:56Z","timestamp":1716523676000},"page":"1339-1348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Age and <scp>BMI<\/scp> have different effects on subcutaneous, visceral, liver, bone marrow, and muscle adiposity, as measured by <scp>CT<\/scp> and <scp>MR<\/scp>I"],"prefix":"10.1002","volume":"32","author":[{"given":"Ling","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics  Beijing China"},{"name":"JST Sarcopenia Research Centre, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital Capital Medical University, National Center for Orthopaedics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics  Beijing 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M.","family":"Blake","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering &amp; Imaging Sciences, King's College London St Thomas' Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4596-8248","authenticated-orcid":false,"given":"Xiaoguang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopaedics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Liu","sequence":"additional","affiliation":[{"name":"JST Sarcopenia Research Centre, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital Capital Medical University, National Center for Orthopaedics  Beijing China"},{"name":"Department of Spine Surgery, Beijing Jishuitan Hospital Capital Medical University, National Center for Orthopaedics  Beijing 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