{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:12:18Z","timestamp":1777464738216,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Considering limited evidence on diagnostics of genetic obesity in adults, we evaluated phenotypes of adults with genetic obesity. Additionally, we assessed the applicability of Endocrine Society (ES) recommendations for genetic testing in pediatric obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared clinical features, including age of onset of obesity and appetite, between adults with non\u2010syndromic monogenic obesity (MO), adults with syndromic obesity (SO), and adults with common obesity (CO) as control patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 79 adults with genetic obesity (32 with MO, 47 with SO) were compared with 186 control patients\u00a0with CO. Median BMI was similar among the groups: 41.2, 39.5, and 38.7\u2009kg\/m<jats:sup>2<\/jats:sup> for patients with MO, SO, and CO, respectively. Median age of onset of obesity was 3 (IQR: 1\u20136) years in patients with MO, 9 (IQR: 4\u201313) years in patients with SO, and 21 (IQR: 13\u201333) years in patients with CO (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Patients with genetic obesity more often reported increased appetite: 65.6%, 68.1%, and 33.9% in patients with MO, SO, and CO, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Intellectual deficit and autism spectrum disorder were more prevalent in patients with SO (53.2% and 21.3%) compared with those with MO (3.1% and 6.3%) and CO (both 0.0%). The ES recommendations were fulfilled in 56.3%, 29.8%, and 2.7% of patients with MO, SO, and CO, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found distinct phenotypes in adult genetic obesity. Additionally, we demonstrated low sensitivity for detecting genetic obesity in adults using pediatric ES recommendations, necessitating specific genetic testing recommendations in adult obesity care.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24047","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T04:48:50Z","timestamp":1716958130000},"page":"1257-1267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical phenotypes of adults with monogenic and syndromic genetic obesity"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9261-5541","authenticated-orcid":false,"given":"Mila S.","family":"Welling","sequence":"first","affiliation":[{"name":"Obesity Center CGG, Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Internal Medicine, Division of Endocrinology Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Pediatrics, Division of Endocrinology Erasmus MC\u2010Sophia Children's Hospital, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Mohseni","sequence":"additional","affiliation":[{"name":"Obesity Center CGG, Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Internal Medicine, Division of Endocrinology Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate E. H.","family":"Meeusen","sequence":"additional","affiliation":[{"name":"Obesity Center CGG, Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Internal Medicine, Division of Endocrinology Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6940-0289","authenticated-orcid":false,"given":"Cornelis J.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Obesity Center CGG, Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Pediatrics, Division of Endocrinology Erasmus MC\u2010Sophia Children's Hospital, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3247-7538","authenticated-orcid":false,"given":"Mari\u00ebtte R.","family":"Boon","sequence":"additional","affiliation":[{"name":"Obesity Center CGG, Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Internal Medicine, Division of Endocrinology Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9106-7478","authenticated-orcid":false,"given":"Lotte","family":"Kleinendorst","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"},{"name":"Emma Center for Personalized Medicine, Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7182-3571","authenticated-orcid":false,"given":"Jenny A.","family":"Visser","sequence":"additional","affiliation":[{"name":"Obesity Center CGG, Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Internal Medicine, Division of Endocrinology Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7519-0246","authenticated-orcid":false,"given":"Mieke M.","family":"van Haelst","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"},{"name":"Emma Center for Personalized Medicine, Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5352-9328","authenticated-orcid":false,"given":"Erica L. 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