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Regional body composition was measured with dual\u2010energy x\u2010ray absorptiometry and a single\u2010slice abdominal computed tomography scan. Mean adipocyte size was measured in abdominal and femoral SAT and was used to quantify morphology in android and gynoid subcutaneous fat, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Abdominal SAT morphology was more hyperplastic in females with CO than females with AO (<jats:italic>p<\/jats:italic>\u2009=\u20090.004) but did not differ between males with CO and males with AO (<jats:italic>p<\/jats:italic>\u2009=\u20090.996). Conversely, femoral SAT morphology was more hypertrophic in males and females with CO than those with AO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Age of obesity onset appears to affect SAT morphology differently in the abdominal and femoral regions of male and female adults. Our findings challenge the notion that SAT is uniformly hyperplastic in CO and hypertrophic in AO.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24059","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T09:35:36Z","timestamp":1721813736000},"page":"1508-1517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8071-4457","authenticated-orcid":false,"given":"Jessica","family":"Murphy","sequence":"first","affiliation":[{"name":"Department of Health, Kinesiology, and Applied Physiology Concordia University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Metabolism, Obesity, and Nutrition Laboratory, School of Health Concordia University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Centre de 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