{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:02Z","timestamp":1786978322047,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA0806100"],"award-info":[{"award-number":["2022YFA0806100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270922"],"award-info":[{"award-number":["82270922"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Thyroid hormone influences key metabolic pathways, and reduced sensitivity to thyroid hormone is considered a new risk factor for adverse metabolic outcomes. However, the association between thyroid hormone resistance and obesity in euthyroid individuals is still unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We enrolled 8021 euthyroid individuals, calculated thyroid hormone resistance indices, and analyzed the association between thyroid hormone resistance and obesity by regression analysis. Furthermore, we conducted the thyrotropin\u2010releasing hormone stimulation test in both control and obese mice (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095) to demonstrate the association.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The euthyroid adults with overweight and obesity had increased thyroid hormone resistance indices (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). BMI and prevalence of overweight and obesity increased (odds ratio of thyroid feedback quantile\u2010based index [OR\n                      <jats:sub>TFQI<\/jats:sub>\n                      ]\u2009=\u20091.164,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036; OR of free triiodothyronine\/free thyroxine [OR\n                      <jats:sub>FT3\/FT4<\/jats:sub>\n                      ]\u2009=\u20091.508,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) following the elevation of thyroid hormone resistance indices. Mediation analysis indicated a complete mediation effect (beta coefficient of indirect effect [\u03b2\n                      <jats:sub>Ind<\/jats:sub>\n                      ]=\u20096.838,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) of metabolic disorders in the relationship. Furthermore, in the mice with obesity, the thyrotropin response to thyrotropin\u2010releasing hormone stimulation (68.33\u201390.89\u2009pg\/mL) was comparatively blunted (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Euthyroid individuals with obesity exhibit both central and peripheral thyroid hormone resistance, a phenomenon that is more pronounced in individuals with metabolic abnormalities. Thyroid hormone resistance is associated with an increased prevalence of overweight and obesity mediated by metabolic disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.24084","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T05:35:36Z","timestamp":1721799336000},"page":"1483-1493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association between thyroid hormone resistance and obesity: a cross\u2010sectional study and mouse stimulation test"],"prefix":"10.1002","volume":"32","author":[{"given":"Zhihui","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"},{"name":"Shandong Key Laboratory of Endocrinology and Lipid Metabolism  Jinan China"},{"name":"Shandong Institute of Endocrine and Metabolic Diseases  Jinan China"},{"name":"\u201cChuangxin China\u201d Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Disease  Jinan China"},{"name":"Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"},{"name":"Shandong Key Laboratory of Endocrinology and Lipid Metabolism  Jinan China"},{"name":"Shandong Institute of Endocrine and Metabolic Diseases  Jinan China"},{"name":"\u201cChuangxin China\u201d Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Disease  Jinan China"},{"name":"Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"},{"name":"Shandong Key Laboratory of Endocrinology and Lipid Metabolism  Jinan China"},{"name":"Shandong Institute of Endocrine and Metabolic Diseases  Jinan China"},{"name":"\u201cChuangxin China\u201d Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Disease  Jinan China"},{"name":"Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8368-3051","authenticated-orcid":false,"given":"Junming","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; 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