{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:57:13Z","timestamp":1774324633281,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018722","name":"Jaap Schouten Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Heart failure (HF) pathophysiology in patients with obesity may be distinct. To study these features, we identified obesity\u2010related biomarkers from 4210 circulating proteins in patients with HF with reduced ejection fraction (HFrEF) and examined associations of these proteins with HF prognosis and biological mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 373 patients with trimonthly blood sampling during a median follow\u2010up of 2.1 (25th\u201375th percentile: 1.1\u20132.6) years, we applied an aptamer\u2010based multiplex approach measuring 4210 proteins in baseline samples and the last two samples before study end. Associations between obesity (BMI\u2009&gt;\u200930\u2009kg\/m<jats:sup>2<\/jats:sup>) and baseline protein levels were analyzed. Subsequently, associations of serially measured obesity\u2010related proteins with biological mechanisms and the primary endpoint (PEP; composite of cardiovascular mortality, HF hospitalization, left ventricular assist device implantation, and heart transplantation) were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Obesity was identified in 26% (96\/373) of patients. A total of 30% (112\/373) experienced a PEP (with obesity: 26% [25\/96] vs. without obesity: 31% [87\/277]). A total of 141\/4210 proteins were linked to obesity, reflecting mechanisms of neuron projection development, cell adhesion, and muscle cell migration. A total of 50\/141 proteins were associated with the PEP, of which 12 proteins related to atherosclerosis or hypertrophy provided prognostic information beyond clinical characteristics, N\u2010terminal pro\u2010B\u2010type natriuretic peptide, and high\u2010sensitivity troponin T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with HFrEF and obesity\u00a0show distinct proteomic profiles compared to patients with HFrEF without obesity. Obesity\u2010related proteins are independently associated with HF outcome. These proteins carry potential to improve management of obesity\u2010related HF and could be leads for future research.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/oby24094-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24094","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T05:29:24Z","timestamp":1721712564000},"page":"1658-1669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Proteomic biomarkers related to obesity in heart failure with reduced ejection fraction and their associations with outcome"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2338-9931","authenticated-orcid":false,"given":"Teun B.","family":"Petersen","sequence":"first","affiliation":[{"name":"Department of Cardiology Thorax Center Cardiovascular Institute, Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Biostatistics Erasmus MC, University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-2897","authenticated-orcid":false,"given":"Navin","family":"Suthahar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thorax Center Cardiovascular Institute, Erasmus MC  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Folkert W.","family":"Asselbergs","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam University Medical Centers, University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"de Bakker","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thorax Center Cardiovascular Institute, Erasmus MC  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Martijn","family":"Akkerhuis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thorax Center Cardiovascular Institute, Erasmus MC  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina A.","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thorax Center Cardiovascular Institute, Erasmus MC  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"van Ramshorst","sequence":"additional","affiliation":[{"name":"Department of Cardiology Northwest Clinics  Alkmaar the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Katsikis","sequence":"additional","affiliation":[{"name":"Department of Immunology Erasmus MC, University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"van der 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