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Linear regression models adjusted for maternal and offspring covariates and cell counts were used to analyze associations between neonatal adiposity as measured by sum of three skinfold thicknesses and cord blood DNA methylation. Assays were performed with Illumina EPIC arrays (791,359 CpG sites after quality control). Replication was performed in an independent cohort, Genetics of Glucose regulation in Gestation and Growth (Gen3G).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 2740 HAPO samples, significant associations were identified at 89 CpG sites after accounting for multiple testing (Bonferroni\u2010adjusted <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Replication analyses conducted in 139 Gen3G participants confirmed associations for seven CpG sites. These included <jats:italic>IGF1R<\/jats:italic>, which encodes a transmembrane receptor involved in cell growth and survival that binds insulin\u2010like growth factor I and insulin, and <jats:italic>KLF7<\/jats:italic>, which encodes a regulator of cell proliferation and inhibitor of adipogenesis; both are key regulators of growth during fetal life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings support epigenetic mechanisms in the developmental origins of neonatal adiposity and as potential biomarkers of metabolic disease risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24109","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T20:02:51Z","timestamp":1724270571000},"page":"1923-1933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Newborn adiposity is associated with cord blood <scp>DNA<\/scp> methylation at <scp>IGF1R<\/scp> and <scp>KLF7<\/scp>"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0339-0166","authenticated-orcid":false,"given":"Jami L.","family":"Josefson","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Northwestern University Feinberg School of Medicine, Division of Endocrinology Ann &amp; Robert H. 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