{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:05:27Z","timestamp":1792123527740,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK\u2010120331"],"award-info":[{"award-number":["DK\u2010120331"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100024223","name":"Echosens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024223","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to determine the prevalence of metabolic dysfunction\u2010associated steatotic liver disease (MASLD) in young compared with older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individuals (<jats:italic>n<\/jats:italic>\u2009=\u20091420) with (63%) and without type 2 diabetes mellitus (T2D; 37%) who attended internal medicine clinics and did not have a known history of MASLD underwent laboratory evaluation and transient elastography to assess for hepatic steatosis and fibrosis. Magnetic resonance elastography and liver biopsy were recommended when indicated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 243 participants were\u2009ages &lt;45\u2009years, and 1177 were\u2009ages \u226545\u2009years. Obesity, T2D, and metabolic syndrome were highly prevalent in young adults. Frequencies of steatosis and fibrosis were high in young adults (50.2% and 7.5% vs. older adults 52.7% and 9.9%, respectively) and were significantly higher in those with both obesity and T2D (71.1% and 15.7%, respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). In young adults, T2D and obesity were the strongest risk factors for hepatic fibrosis (odds ratios 4.33 [95% CI: 1.37\u201313.68] and 1.16 [95% CI: 1.07\u20131.25], respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a high prevalence of clinically significant hepatic fibrosis in young adults with cardiometabolic risk factors. Up to one in seven young adults with obesity and T2D had clinically significant hepatic fibrosis on elastography. This highlights the need to screen young adults with cardiometabolic risk factors for MASLD for early detection and intervention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24130","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T04:34:43Z","timestamp":1727152483000},"page":"1967-1974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Obesity increases the risk of hepatic fibrosis in young adults with type 2 diabetes mellitus: the need to screen"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0435-2201","authenticated-orcid":false,"given":"Anu","family":"Sharma","sequence":"first","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddison","family":"Godinez Leiva","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srilaxmi","family":"Kalavalapalli","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Lomonaco","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Marangi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Valdez Saenz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ortiz Rocha","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaly","family":"Cuervo Pardo","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Advanced Magnetic Resonance Imaging and Spectroscopy Facility, McKnight Brain Institute University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bedossa","sequence":"additional","affiliation":[{"name":"Department of Pathology H\u00f4pital Beaujon AP\u2010HP  Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Bril","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Barb","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8629-418X","authenticated-orcid":false,"given":"Kenneth","family":"Cusi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.2337\/dc24-S004","article-title":"4. 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