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Tissue lipolytic capacity was determined by measurement of secreted glycerol. Cellular insulin signaling was determined by measuring insulin\u2010mediated changes in Akt phosphorylation. RNA sequencing examined global transcriptional changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With SSD, basal glycerol secretion was reduced, and isoproterenol\u2010stimulated lipolysis was attenuated. Insulin concentration\u2010dependent increases in phosphorylated Akt observed in samples after habitual sleep were abrogated after SSD. However, insulin\u2010mediated suppression of lipolysis remained unaltered with changes in sleep duration. Increased transcription of genes involved in adipogenesis and fatty acid metabolism was observed after SSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SSD blunts adrenergic stimulation of lipolysis without altering insulin\u2010mediated suppression of lipolysis in postmenopausal women. These changes in adipose tissue may potentiate fat gain independent of caloric intake. Therefore, interventions promoting sleep may be considered to mitigate abdominal adiposity in postmenopausal women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24162","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T01:29:07Z","timestamp":1730078947000},"page":"2264-2274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Shortened sleep duration impairs adipose tissue adrenergic stimulation of lipolysis in postmenopausal women"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7392-9035","authenticated-orcid":false,"given":"Prachi","family":"Singh","sequence":"first","affiliation":[{"name":"Pennington Biomedical Research Center  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbie A.","family":"Beyl","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center  Baton Rouge 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