{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:18:20Z","timestamp":1773422300597,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK045735"],"award-info":[{"award-number":["P30DK045735"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001863"],"award-info":[{"award-number":["UL1TR001863"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["R01MD015974"],"award-info":[{"award-number":["R01MD015974"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Pediatric obesity is associated with insulin resistance, which, in turn, impacts glucose and lipid metabolism. This study sought to assess how glucose variability relates to intrahepatic fat content, \u03b2 cell insulin sensitivity, and glycolysis in youth with obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 27 youth with obesity (11 girls, BMI percentile, median [25th\u201375th percentiles]: 99.0 [97.9\u201399.0]) wore a continuous glucose monitoring device for 10\u2009days and underwent a 3\u2010h oral glucose tolerance test. \u03b2 cell function was assessed using the oral minimal model, and liver proton density fat fraction was measured by magnetic resonance imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average sensor\u2010derived glucose and glucose standard deviation (STDEV) and coefficient of variation (CV) were associated with liver proton density fat fraction\u00a0(<jats:italic>p<\/jats:italic>\u2009=\u20090.0130, <jats:italic>p<\/jats:italic>\u2009=\u20090.0005, and <jats:italic>p<\/jats:italic>\u2009=\u20090.0028, respectively). First\u2010phase insulin secretion, basal insulin secretion, and insulin sensitivity were associated with STDEV (<jats:italic>p<\/jats:italic>\u2009=\u20090.0344, <jats:italic>p<\/jats:italic>\u2009=\u20090.0091, and <jats:italic>p<\/jats:italic>\u2009=\u20090.0031, respectively) and CV (<jats:italic>p<\/jats:italic>\u2009=\u20090.0128, <jats:italic>p<\/jats:italic>\u2009=\u20090.0012, and <jats:italic>p<\/jats:italic>\u2009=\u20090.0022, respectively). STDEV and CV were also associated with 2\u2010h glucose (<jats:italic>p<\/jats:italic>\u2009=\u20090.0067 and <jats:italic>p<\/jats:italic>\u2009=\u20090.0324, respectively) and plasma lactate (<jats:italic>p<\/jats:italic>\u2009=\u20090.0030 and <jats:italic>p<\/jats:italic>\u2009=\u20090.0123, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Daily glucose variability is associated with the degree of intrahepatic fat content, postprandial glucose, and plasma lactate concentrations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24175","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T03:38:30Z","timestamp":1733888310000},"page":"116-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Daily glucose variability is associated with intrahepatic fat content, \u03b2 cell sensitivity, and biomarkers of glycolysis in youth with obesity"],"prefix":"10.1002","volume":"33","author":[{"given":"Emiliano","family":"Barbieri","sequence":"first","affiliation":[{"name":"Scuola di Specializzazione in Pediatria, Universita' Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4097-7943","authenticated-orcid":false,"given":"Jacopo","family":"Bonet","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, University of Padova  Padua Italy"},{"name":"Department of Pediatrics Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delaney","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansas University Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafaela","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansas University Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansas University Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loretta","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansas University Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Center for Children's Healthy Lifestyles &amp; Nutrition, Kansas University Medical Center  Kansas City Kansas USA"},{"name":"University of Missouri\u2010Kansas City School of Medicine  Kansas City Kansas USA"},{"name":"Division of Weight Management Children's Mercy  Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Van Name","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-9841","authenticated-orcid":false,"given":"Stephanie","family":"Samuels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Caprio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Sabati","sequence":"additional","affiliation":[{"name":"Hoglund Biomedical Imaging Center, Kansas University Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Galderisi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Sherr","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Dalla Man","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, University of Padova  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6437-4173","authenticated-orcid":false,"given":"Nicola","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Medicine and Health Sciences \"V. 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