{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:25:48Z","timestamp":1785939948618,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study objective was to evaluate changes in abdominal adipose tissue and ectopic fat during pregnancy and their associations with gestational weight gain (GWG) in women with overweight\/obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a secondary analysis of a randomized controlled trial. Magnetic resonance scans were performed during gestational week (GW) 15, GW 32, and around birth to measure abdominal subcutaneous (SAT) and visceral (VAT) adipose tissues, liver fat, and muscle fat. Linear mixed models and multivariable linear regression analyses were utilized, adjusting for prepregnancy BMI, parity, and randomization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 119 women, VAT and SAT decreased from GW 15 to GW 32 but rebounded at birth; final levels were lower than at GW 15. Liver fat and muscle fat did not change significantly. GWG was positively associated with changes in SAT but not with those in VAT, liver fat, or muscle fat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates dynamic changes in abdominal fat depots during pregnancy in women with overweight\/obesity. The observed reduction in VAT and SAT during pregnancy and the association of GWG with SAT suggest that weight gain during pregnancy may be less metabolically harmful than outside pregnancy. Future research should investigate the mechanisms and long\u2010term effects on maternal and child health.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24176","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T04:32:11Z","timestamp":1735878731000},"page":"238-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Changes in abdominal adipose tissues and ectopic fat depots during pregnancy are dissociated from gestational weight gain"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5098-4843","authenticated-orcid":false,"given":"Christina Sonne","family":"Mogensen","sequence":"first","affiliation":[{"name":"Department of Nutrition, Exercise and Sports, Faculty of Science University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faidon","family":"Magkos","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports, Faculty of Science University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta","family":"Chabanova","sequence":"additional","affiliation":[{"name":"Department of Radiology Copenhagen University Hospital Herlev\u2010Gentofte  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"M\u00f8lgaard","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports, Faculty of Science University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina Rica Wium","family":"Geiker","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports, Faculty of Science University of Copenhagen  Copenhagen Denmark"},{"name":"Centre for Childhood Health  Copenhagen Denmark"},{"name":"Dietetic and Clinical Nutrition Research Unit Copenhagen University Hospital Herlev\u2010Gentofte  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Institute of Medicine N.r.c. Weight Gain During Pregnancy: Reexamining the Guidelines.National Academies Press;2009."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.34.4.380"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90731-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91306-W"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000242614"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22699"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30084-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.142"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13091016"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-04-0285"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05488"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232155"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurox.2020.100117"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqab405"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.2.362"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.111203"},{"key":"e_1_2_10_18_1","unstructured":"Royal College of Pediatrics and Child Health.BOYS UK\u2013WHO Neonatal and Infant Close Monitoring Growth Chart. 23\u2009weeks gestation to 2\u2009years corrected age. Accessed May 5 2024.https:\/\/www.rcpch.ac.uk\/sites\/default\/files\/Boys_neonatal_and_infant_close_monitoring_growth_chart.pdf"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4172\/2472-1182.1000106"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.24176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T10:11:49Z","timestamp":1753006309000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.24176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/oby.24176"],"URL":"https:\/\/doi.org\/10.1002\/oby.24176","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,3]]},"assertion":[{"value":"2024-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}