{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:34:59Z","timestamp":1788878099681,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to describe the prevalence of obesity, obesity\u2010related conditions (ORCs), and antiobesity medication (AOM) eligibility and prescribing practice among eligible patients in a large health care system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional analysis of the multicenter Mass General Brigham health care system (Boston, Massachusetts) spanning 2018 to 2022, adults eligible for AOMs (BMI\u2009\u2265\u200930\u2009kg\/m<jats:sup>2<\/jats:sup> or BMI 27\u201329.9\u2009kg\/m<jats:sup>2<\/jats:sup> with \u22651 ORC) were identified. Among those AOM\u2010eligible, the prevalence of prescriptions for AOMs approved for long\u2010term weight management was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2,469,474 adults (mean [SD], age 53\u2009[19]\u2009years; 57% female; BMI 28.1\u2009[6.3]\u2009kg\/m<jats:sup>2<\/jats:sup>), a total of 1,110,251 (45.0%) were eligible for AOMs. Of these, 69.4% (31.2% of overall cohort) had BMI\u2009\u2265\u200930\u2009kg\/m<jats:sup>2<\/jats:sup>. AOM prescription was observed in 15,214 (1.4%) of all eligible patients, with female sex, younger age, higher BMI, commercial insurance, and greater ORC burden associated with higher prevalence of AOM prescriptions. Musculoskeletal disorders (54%) were the most common ORCs, with \u22652\u00a0ORCs observed in 62% of patients. Liraglutide 3.0\u2009mg and semaglutide 2.4\u2009mg were the most frequently prescribed AOMs (58% and 34% of all AOMs, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although nearly one\u2010half of all patients in a large health care system were AOM\u2010eligible by guidelines and regulatory labeling, only 1% of those who were eligible were prescribed AOMs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24186","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:18:11Z","timestamp":1734567491000},"page":"365-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Contemporary treatment patterns of overweight and obesity: insights from the Mass General Brigham health care system"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2866-9414","authenticated-orcid":false,"given":"John W.","family":"Ostrominski","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Division of Endocrinology, Diabetes and Hypertension Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavishwar B.","family":"Wagholikar","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Lab of Computer Science Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Olsson","sequence":"additional","affiliation":[{"name":"Novo Nordisk Inc.  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Plainsboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Michalak","sequence":"additional","affiliation":[{"name":"Novo Nordisk Inc.  Plainsboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Fabricatore","sequence":"additional","affiliation":[{"name":"Novo Nordisk Inc.  Plainsboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Br\u00edain \u00d3.","family":"Hartaigh","sequence":"additional","affiliation":[{"name":"Novo Nordisk Inc.  Plainsboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Baer","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of General Internal Medicine and Primary Care Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard T.H. Chan School of Public Health Harvard University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8029-1922","authenticated-orcid":false,"given":"Caroline M.","family":"Apovian","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi D. 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