{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:20:32Z","timestamp":1788780032989,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1S10RR023405\u201001"],"award-info":[{"award-number":["1S10RR023405\u201001"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1UL1TR001102"],"award-info":[{"award-number":["1UL1TR001102"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1UL1TR002541\u201001"],"award-info":[{"award-number":["1UL1TR002541\u201001"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23DK110419"],"award-info":[{"award-number":["K23DK110419"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K24DK109940"],"award-info":[{"award-number":["K24DK109940"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K24HD071843"],"award-info":[{"award-number":["K24HD071843"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K24MH120568"],"award-info":[{"award-number":["K24MH120568"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK057521"],"award-info":[{"award-number":["P30DK057521"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK103946"],"award-info":[{"award-number":["R01DK103946"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Mechanisms underlying metabolic improvement following metabolic and bariatric surgery (MBS) may provide insight into novel therapies. Vasopressin improves body composition and protects against hypoglycemia. Associations of copeptin, a stable cleavage product of vasopressin, with BMI and insulin resistance suggest an adaptive increase in vasopressin to counteract metabolic disruption. To our knowledge, no study has investigated copeptin before and after MBS in humans. This study's aim was to investigate copeptin changes following MBS and associations with metabolic parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a 12\u2010month longitudinal study of 64 youth (78% female; mean age 18.7\u2009[SD 2.8]\u2009y) with obesity (mean BMI 45.6\u2009[SD 6.8]\u2009kg\/m<jats:sup>2<\/jats:sup>) undergoing MBS (<jats:italic>n<\/jats:italic>\u2009=\u200934) or nonsurgical (NS) lifestyle management (<jats:italic>n<\/jats:italic>\u2009=\u200930). Fasting copeptin, hemoglobin A1c (HbA1c), homeostatic model assessment for insulin resistance (HOMA\u2010IR), body composition, and resting energy expenditure (REE) were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 12\u2009months, copeptin increased more (time\u2010by\u2010treatment <jats:italic>p<\/jats:italic>\u2009=\u20090.017) whereas HbA1c and adiposity decreased more after MBS than NS (<jats:italic>ps<\/jats:italic>\u2009\u2264\u20090.036). Copeptin changes correlated negatively with percentage fat mass and REE changes (rho\u2009\u2264\u2009\u22120.29; <jats:italic>p<\/jats:italic>s\u2009\u2264\u20090.025) in the whole group, and they correlated positively with HbA1c and HOMA\u2010IR (rho\u2009\u2265\u20090.41; false discovery rate\u2013adjusted <jats:italic>p<\/jats:italic> =\u20090.05) and negatively with REE changes (rho\u2009=\u2009\u22120.55; false discovery rate\u2013adjusted <jats:italic>p<\/jats:italic>\u2009=\u20090.036) in the MBS group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increases in copeptin after weight loss in MBS compared with NS were associated with lower REE and higher HbA1c\/HOMA\u2010IR values. Vasopressin may contribute to MBS\u2010related metabolic modifications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24200","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T21:32:06Z","timestamp":1735248726000},"page":"298-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increased copeptin may reflect vasopressin\u2010related metabolic changes after bariatric surgery"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0744-2541","authenticated-orcid":false,"given":"Francesca","family":"Galbiati","sequence":"first","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Becetti","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Lauze","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Aulinas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition Hospital de la Santa Creu i Sant Pau, IR\u2010Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9729-4433","authenticated-orcid":false,"given":"Vibha","family":"Singhal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Pediatrics Mattel Childrens' Hospital, UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam A.","family":"Bredella","sequence":"additional","affiliation":[{"name":"Department of Radiology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Radiology NYU Langone Health and Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Lawson","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9405-2981","authenticated-orcid":false,"given":"Madhusmita","family":"Misra","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Pediatric Endocrinology, Department of Pediatrics Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Pediatric Endocrinology, Department of Pediatrics University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.09.017"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241210144"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010820107\u20107.00006\u20109"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.115"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010015\u20103496\u20109"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2021.170555"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424\u2010008\u20100498\u20101"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000054557"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u2010444\u201059602\u20104.00004\u20106"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1989.sp003294"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109384(91)90251\u2010i"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005570"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2011\u20101049"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/235426"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.06.010"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem\u201065\u20101\u2010116"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000045879"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.28.5.503"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00269.2016"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016\u20101113"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.060038"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.909663"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010\u20102981"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201015\u20100781"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26382"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2012.88"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010013\u20102683\u20105"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010020\u201003777\u20103"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13235"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem\u20102020\u20100240"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.15355"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem\u20102022\u20100525"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15173801"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad390"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.04.008"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2006\u20100069"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2014.967677"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.05\u201001\u201000234.1985"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12649"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.47.557"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2023.02.012"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010021\u201005277\u20101"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2002.34052"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-019-0445-6"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23520"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.24200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T10:11:39Z","timestamp":1753006299000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.24200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/oby.24200"],"URL":"https:\/\/doi.org\/10.1002\/oby.24200","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,26]]},"assertion":[{"value":"2024-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}