{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:54:52Z","timestamp":1762509292855,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK092237\u201001","DK092237\u201002S2","DK57136\u2010DK56992"],"award-info":[{"award-number":["DK092237\u201001","DK092237\u201002S2","DK57136\u2010DK56992"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG03308701","R01AG058571"],"award-info":[{"award-number":["R01AG03308701","R01AG058571"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to investigate the longitudinal association of total body fat and appendicular lean mass (ALM), as well as sarcopenia, with cognitive decline after weight loss intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among 972 Look AHEAD\u2010MIND participants with type 2 diabetes and overweight or obesity, we investigated the longitudinal association of dual\u2010energy x\u2010ray absorptiometry body composition trajectories with cognitive change. We identified three latent trajectories each for total body fat and ALM. Mixed linear regression models were adjusted for the following: repeated measures; order of cognitive test; years from randomization; randomization arm; age; sex; race and ethnicity; and education. We also investigated differences in cognitive score by sarcopenia and BMI categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A gradual decrease in total body fat and no decrease in ALM were significantly independently associated with higher cognitive scores compared with other trajectories. Differences in cognitive score were large for sarcopenia, but not for obesity. Full adjustment for demographic and socioeconomic factors substantially attenuated the estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Weight loss approaches that preserve ALM and function may lead to reduced cognitive decline compared with weight loss alone. The improved ability to target interventions toward those who are more resilient to aging\u2010related body composition changes may prevent unintended consequences of weight loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.24212","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T04:24:37Z","timestamp":1753071877000},"page":"86-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of body composition trajectories with changes in cognitive performance in the Look\n                    <scp>AHEAD<\/scp>\n                    study"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6541-7198","authenticated-orcid":false,"given":"Morgana","family":"Mongraw\u2010Chaffin","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Prevention Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joni K.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Sciences Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather M.","family":"Shappell","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Sciences Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3711-1949","authenticated-orcid":false,"given":"Mark A.","family":"Espeland","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Sciences Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"},{"name":"Department of Geriatrics and Gerontology Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7745-3513","authenticated-orcid":false,"given":"Kathleen M.","family":"Hayden","sequence":"additional","affiliation":[{"name":"Department of Social Sciences and Health Policy Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.11.017"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afv151"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20037"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12989"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2015.243"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008733"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328312c37d"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-013-9992-0"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25077"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0084-z"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12652"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2014.117"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010805"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115407"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(03)00064-3"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1212914"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.84"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774511405858"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0762"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1483"},{"issue":"32","key":"e_1_2_11_22_1","first-page":"780","article-title":"Altered body composition in type 2 diabetes mellitus","volume":"2008","author":"Heshka S","year":"2005","journal-title":"Int J Obes (Lond)"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21005"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24025"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu010"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.3.694"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113637"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-019-1287-6"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2023.02.018"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521241"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2012.20"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14692"},{"key":"e_1_2_11_33_1","first-page":"314","article-title":"The Modified Mini\u2010Mental State (3MS) examination","volume":"48","author":"Teng EL","year":"1987","journal-title":"J Clin Psychiatry"},{"volume-title":"L'examen clinique en psychologie","year":"1958","author":"Rey A.","key":"e_1_2_11_34_1"},{"volume-title":"Wechsler Adult Intelligence Scale\u2010III (WAIS\u2010III)","year":"1997","author":"Wechsler D","key":"e_1_2_11_35_1"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0054651"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1958.8.3.271"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517160"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxad010"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1017\/S000711452000224X"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.07.004"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2011.03.006"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2017.04.007"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319997"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982704"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803761"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.24212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T05:53:12Z","timestamp":1762494792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.24212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,20]]},"references-count":45,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/oby.24212"],"URL":"https:\/\/doi.org\/10.1002\/oby.24212","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"type":"print","value":"1930-7381"},{"type":"electronic","value":"1930-739X"}],"subject":[],"published":{"date-parts":[[2025,7,20]]},"assertion":[{"value":"2024-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}