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We aimed to systematically review weight\u2010loss interventions for adolescents with DS to better understand the most effective strategies and identify the current gaps in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic review followed Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) guidelines (International Prospective Register of Systematic Reviews [PROSPERO] #CRD42022303781). Databases were searched through July 28, 2023, and screening, evaluation, and data extraction were performed by two independent reviewers. Change scores for weight or BMI were presented by study design and intervention components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 26 included papers describing 24 unique studies included a total of <jats:italic>n<\/jats:italic>\u2009=\u20091171 participants, of whom <jats:italic>n<\/jats:italic>\u2009=\u2009393 were participants with DS. Eleven studies focused on physical activity, one on diet, and two on physical activity and diet; seven studies used multicomponent interventions; and three studies investigated laparoscopic sleeve gastrectomy. Thirteen studies using either a multicomponent intervention, a physical activity intervention, or surgery resulted in weight loss or a decrease in BMI in adolescents with DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Weight\u2010loss interventions can be effective for adolescents with DS and could benefit from increasing duration\/intensity to meet the existing weight\u2010loss intervention recommendations. More research on surgery and weight\u2010loss medications is needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24233","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:01:27Z","timestamp":1741741287000},"page":"632-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Weight\u2010loss interventions for adolescents with Down syndrome: a systematic review"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9882-163X","authenticated-orcid":false,"given":"Thessa I.M.","family":"Hilgenkamp","sequence":"first","affiliation":[{"name":"Department of Physical Therapy University of Nevada  Las Vegas Las Vegas, Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Davidson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith M.","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Fleming","sequence":"additional","affiliation":[{"name":"Department of Exercise and Health Sciences University of Massachusetts Boston  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Foster Kirk","sequence":"additional","affiliation":[{"name":"Hinge Health  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9487-6748","authenticated-orcid":false,"given":"Mary","family":"Hastert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Kim","sequence":"additional","affiliation":[{"name":"People's Community Clinic  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Mann","sequence":"additional","affiliation":[{"name":"Mann Method Physical Therapy and Fitness  Arvada Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Usseglio","sequence":"additional","affiliation":[{"name":"Augustus C. 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