{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:20:39Z","timestamp":1765808439945,"version":"3.41.2"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01ES031065","R01HD034568","R01HD096032","R24ES030894","T32HD104612"],"award-info":[{"award-number":["R01ES031065","R01HD034568","R01HD096032","R24ES030894","T32HD104612"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30 ES000002"],"award-info":[{"award-number":["P30 ES000002"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to evaluate associations of early\u2010pregnancy plasma per\u2010 and polyfluoroalkyl substances (PFAS) with maternal post\u2010pregnancy weight trajectory parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 1106 Project Viva participants with measures of early\u2010pregnancy plasma concentrations of eight PFAS. We measured weight at in\u2010person visits at 6\u2009months and 3, 7, and 12\u2009years after pregnancy and collected self\u2010reported weight via annual questionnaires up to 17\u2009years after pregnancy. Weight trajectory parameters were estimated via the Superimposition by Translation and Rotation model. We assessed individual and joint effects of PFAS with trajectory parameters using linear regression and Bayesian kernel machine regression (BKMR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Perfluorooctane sulfonate (PFOS) concentrations were positively associated with weight trajectory magnitude in both linear regression (0.8\u2009kg [95% CI: 0.1 to 1.4] per doubling of PFOS) and BKMR analyses (2.6\u2009kg [95% CI: 1.4 to 3.8] per increase from 25th to 75th percentile of PFOS concentrations). Conversely, in BKMR analyses, perfluorononanoate was negatively associated with trajectory magnitude (\u22122.0\u2009kg [95% CI: \u22122.9 to \u22121.1]). In stratified linear regression, older\u2010aged participants had more pronounced positive associations of PFOS, perfluorooctanoate, and 2\u2010(N\u2010ethyl\u2010perfluorooctane sulfonamido) acetate with weight trajectory velocity. No associations were observed with the overall PFAS mixture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Select PFAS, assessed in pregnancy, may affect maternal weight trajectories spanning 17\u2009years after pregnancy, especially for older\u2010aged individuals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24250","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T23:08:57Z","timestamp":1741820937000},"page":"807-816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early\u2010pregnancy per\u2010 and polyfluoroalkyl substances and maternal post\u2010pregnancy weight trajectory"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-6997","authenticated-orcid":false,"given":"Jordan A.","family":"Burdeau","sequence":"first","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Briana J. K.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9239-7476","authenticated-orcid":false,"given":"Izzuddin M.","family":"Aris","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Life Course, Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shruthi","family":"Mahalingaiah","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-9630","authenticated-orcid":false,"given":"Jorge E.","family":"Chavarro","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma V.","family":"Preston","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010France","family":"Hivert","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Life Course, Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"},{"name":"Diabetes Unit Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Oken","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Life Course, Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia M.","family":"Calafat","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheryl L.","family":"Rifas\u2010Shiman","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Life Course, Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ami R.","family":"Zota","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences Columbia University Mailman School of Public Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamarra","family":"James\u2010Todd","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. 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