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Sites simultaneously related to GWG and children's BMI were validated in an external dataset. The mediation effect of target differential methylation probes in the association between GWG and children's BMI was also explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 66 GWG\u2010related differential methylation probes in cord blood, and four sites, including cg09973771 (<jats:italic>SNTG2<\/jats:italic>), cg00254258 (<jats:italic>PRDM16<\/jats:italic>), cg02672830 (<jats:italic>MCPH1<\/jats:italic>), and cg15424377, were found to be associated with children's BMI at age 3\u2009years. The mediating effect of cord blood DNA methylation was not detected in the association between GWG and children's high BMI status. Out of the four sites screened, methylation level of site cg09973771 (<jats:italic>SNTG2<\/jats:italic>) in peripheral blood showed nominal significant differences among children with different BMI statuses at age 3\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maternal GWG and childhood BMI status at age 3\u2009years were associated with newborn cord blood DNA methylation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24257","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:14:27Z","timestamp":1742429667000},"page":"766-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The associations among maternal gestational weight gain, cord blood <scp>DNA<\/scp> methylation, and offspring childhood high <scp>BMI<\/scp>"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2845-8064","authenticated-orcid":false,"given":"Yuanyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Maternal and Child Health, School of Public Health Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Center for Evidence\u2010Based and Translational Medicine Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8266-7073","authenticated-orcid":false,"given":"Hong","family":"Mei","sequence":"additional","affiliation":[{"name":"Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital) Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixia","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, School of Public Health Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, School of Public Health Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhuhai Center for Maternal and Child Health Care  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7942-8362","authenticated-orcid":false,"given":"Jianduan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, School of Public Health Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Key Laboratory of Environment and Health, Ministry of Education &amp; Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization.Obesity and overweight. 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