{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:23:42Z","timestamp":1776587022043,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01DK072493"],"award-info":[{"award-number":["U01DK072493"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1DK072493"],"award-info":[{"award-number":["UM1DK072493"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1DK095710"],"award-info":[{"award-number":["UM1DK095710"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The long\u2010term durability of improvements in functional mobility and musculoskeletal pain for adolescents after metabolic and bariatric surgery (MBS) is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the Teen\u2010Longitudinal Assessment of Bariatric Surgery (Teen\u2010<jats:styled-content style=\"fixed-case\">LABS<\/jats:styled-content>) study to determine the change in mobility and pain among adolescents who underwent <jats:styled-content style=\"fixed-case\">MBS<\/jats:styled-content>. From standardized 400\u2010m walk tests, we analyzed walk time, heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) parameters, and musculoskeletal pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean walk time improved from 383\u2009s (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 368\u2013399) prior to surgery to 351\u2009s (95% CI: 330\u2013372) by 6\u2009years. The mean resting <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> was 90\u2009beats per minute (bpm; 95% CI: 87\u201393) preoperatively and decreased to 80\u2009bpm (95% CI: 76\u201384) by 6\u2009years. The risk of any musculoskeletal pain decreased from 37.2% (95% CI: 25.5%\u201348.9%) to 11.0% (95% CI: 4.3%\u201317.6%) by 6\u2009years. Mediation analysis revealed that the effect of time since surgery on walk time, resting <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> recovery occurred through a weight\u2010dependent mechanism. For posttest <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> difference, there was both a significant weight\u2010dependent and weight\u2010independent mechanism. The effect of surgery on the risk of musculoskeletal pain occurred through a weight\u2010independent mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adolescents who underwent MBS experienced significant, durable improvement in mobility and pain, despite weight regain. Our models suggest that improvements may occur through a weight\u2010independent mechanism.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24285","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T02:50:25Z","timestamp":1745290225000},"page":"1126-1135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional mobility and pain are improved for 6\u2009years after adolescent bariatric surgery"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3398-6710","authenticated-orcid":false,"given":"Neil","family":"Thivalapill","sequence":"first","affiliation":[{"name":"Department of Surgery Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd M.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Department of Pediatrics Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7782-1112","authenticated-orcid":false,"given":"Thomas H.","family":"Inge","sequence":"additional","affiliation":[{"name":"Department of Surgery Northwestern University Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changchun","family":"Xie","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita P.","family":"Courcoulas","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carroll M.","family":"Harmon","sequence":"additional","affiliation":[{"name":"John R. Oishei Children's Hospital and Jacobs School of Medicine and Biomedical Sciences, State University of New York University at Buffalo  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Helmrath","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Sisley","sequence":"additional","affiliation":[{"name":"US Department of Agriculture\/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc P.","family":"Michalsky","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nationwide Children's Hospital and The Ohio State University College of Medicine Columbus  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin R.","family":"Ryder","sequence":"additional","affiliation":[{"name":"Department of Surgery Northwestern University Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Teen\u2010Longitudinal Assessment of Bariatric Surgery (Teen\u2010LABS) consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.1196"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22196"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019\u20101399"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.0378"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182a5cfb3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.06.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.00724.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12848"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13431"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-020-05160-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13668-018-0243-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2020.03.034"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1813909"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506699"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.5763"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-021-08329-w"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000217592.04061.d5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0557"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035622"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X1101100401"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-014-1560-z"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.3010"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.31593"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1381\/096089206776945084"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004369"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.24285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T09:15:52Z","timestamp":1752743752000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.24285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,21]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/oby.24285"],"URL":"https:\/\/doi.org\/10.1002\/oby.24285","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,21]]},"assertion":[{"value":"2024-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}