{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:44:11Z","timestamp":1787503451141,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>People with early\u2010onset obesity (diagnosed at age &lt;\u200925\u2009years) may present with more cardiometabolic abnormalities and obesity\u2010related complications. This post hoc analysis assessed baseline characteristics and body weight (BW) changes with tirzepatide in people with early\u2010 versus later\u2010onset obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20093782) from SURMOUNT\u20101, SURMOUNT\u20103, and SURMOUNT\u20104 randomized to tirzepatide or placebo were included. Baseline characteristics and changes in BW and cardiometabolic risk factors at 72\/88\u2009weeks were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In SURMOUNT\u20101, participants with early\u2010 versus later\u2010onset obesity had longer mean obesity duration (20\u2009\u00b1\u200912 vs. 11\u2009\u00b1\u20098\u2009years), higher BMI (40\u2009\u00b1\u20097 vs. 37\u2009\u00b1\u20096\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and waist circumference (WC, 118\u2009\u00b1\u200916 vs. 112\u2009\u00b1\u200914\u2009cm), and lower HbA1c (5.48%\u2009\u00b1\u20090.4% vs. 5.60%\u2009\u00b1\u20090.4%), triglycerides (median 120 vs. 130\u2009mg\/dL), and systolic blood pressure (SBP; 121\u2009\u00b1\u200913 vs. 125\u2009\u00b1\u200913\u2009mmHg) at baseline (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.004). At 72\u2009weeks, improvements with tirzepatide in BW (\u221223% vs. \u221222%), WC (\u221222 vs. \u221219\u2009cm), HbA1c (\u22120.51% vs. \u22120.52%), triglycerides (\u221232% vs. \u221231%), and SBP (\u22128 vs. \u22128\u2009mmHg) were similar between subgroups. Similar improvements were observed in SURMOUNT\u20103 and SURMOUNT\u20104.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this post hoc analysis, participants with early\u2010 versus later\u2010onset obesity exhibited a mixed profile of metabolic health at baseline, including a higher degree of central adiposity and lower HbA1c and SBP. Improvements in BW and cardiometabolic markers with tirzepatide were similar between subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifiers: NCT04184622, NCT04657016, NCT04660643\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/oby24348-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.24348","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T03:09:33Z","timestamp":1753672173000},"page":"1668-1679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early\u2010Onset Obesity and Tirzepatide Treatment: A Post Hoc Analysis of the\n                    <scp>SURMOUNT<\/scp>\n                    Clinical Trials"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5788-7955","authenticated-orcid":false,"given":"Evgenia","family":"Gourgari","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics Georgetown University  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8326-3089","authenticated-orcid":false,"given":"Gitanjali","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology &amp; Metabolism, Department of Medicine Vanderbilt University School of Medicine  Nashville Tennessee USA"},{"name":"Department of Surgery Vanderbilt University School of Medicine  Nashville Tennessee USA"},{"name":"Department of Pediatrics Vanderbilt University School of Medicine  Nashville Tennessee USA"},{"name":"Vanderbilt Weight Loss Center Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8530-107X","authenticated-orcid":false,"given":"Aaron S.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Center for Pediatric Obesity Medicine University of Minnesota Medical School  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Mojdami","sequence":"additional","affiliation":[{"name":"Eli Lilly Canada Inc.  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