{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:17:24Z","timestamp":1791605844349,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the added effect of acarbose to orlistat on relative weight loss in the novel antiobesity medication EMP16.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this 6\u2010month double\u2010blind trial, 240 individuals with obesity or overweight and comorbidities were randomized equally into three groups: (1) EMP16 (120\u2009mg modified release orlistat\/40\u2009mg modified release acarbose), (2) MR\u2010O (120\u2009mg modified release orlistat), and (3) Conv\u2010O (120\u2009mg conventional orlistat). The primary outcomes were relative and categorical weight loss after 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean relative weight loss was \u22127.73% for the EMP16 group as compared to \u22125.78% for the MR\u2010O group and \u22125.13% for the Conv\u2010O group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Proportion achieving \u2265\u20095% or \u2265\u200910% weight reduction was 61%\/32% in EMP16 group, compared to 51%\/20% in the MR\u2010O and 48%\/12% in the Conv\u2010O group (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05 for \u2265\u200910%). All groups showed small improvements in glucose and lipid markers, with EMP16 demonstrating greater improvement in fatty liver index and quality of life compared to Conv\u2010O (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). No serious adverse events occurred; most AEs were mild and transient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acarbose enhances the weight loss efficacy of EMP16, supporting its potential as a safe and effective treatment for long\u2010term obesity management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>EU Clinical Trials Register: EudraCT\u2010nr. 2022\u2010003320\u201040<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24369","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T02:10:03Z","timestamp":1754532603000},"page":"1855-1864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Supportive Effect of Acarbose to Orlistat in Weight Management\u2014A Randomized, Double\u2010Blind, Multiarm Phase 2 Trial"],"prefix":"10.1002","volume":"33","author":[{"given":"Ulf","family":"Holmb\u00e4ck","sequence":"first","affiliation":[{"name":"Department of Public Health and Caring Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7532-6465","authenticated-orcid":false,"given":"Stefan","family":"Grud\u00e9n","sequence":"additional","affiliation":[{"name":"Empros Pharma AB  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Kuusk","sequence":"additional","affiliation":[{"name":"Clinical Trial Consultants AB  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Litorp","sequence":"additional","affiliation":[{"name":"Clinical Trial Consultants AB  Uppsala Sweden"},{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"},{"name":"Department of Global Public Health Karolinska Institutet  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