{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:58:14Z","timestamp":1787579894751,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202006380029"],"award-info":[{"award-number":["202006380029"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the association between dietary macronutrient composition and 12\u2010month weight loss maintenance (WLM) in adults who achieved initial weight loss (\u2265\u20095%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort analysis used 12\u2010month follow\u2010up data from the Navigating to a Healthy Weight trial. Macronutrient composition (%) was assessed using a 4\u2010day, 24\u2010h dietary recall. Food sources were categorized as discretionary foods, lean meat, vegetables, fruit, grains, and dairy. Primary outcomes included 12\u2010month changes in body weight, fat mass index (FMI), waist\u2010to\u2010height ratio (WHtR), and hip\u2010to\u2010height ratio (HHtR). A nutritional geometry approach was used to examine individual and interactive associations of macronutrient intake, visualizing as response surfaces.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1518 participants (69.8% women; mean age 45\u2009\u00b1\u200912\u2009years), mean macronutrient composition was 20.6% protein, 33.8% fat, and 43.1% carbohydrate. Protein energy percentage was inversely associated with energy intake (\u03b2: \u22120.33; 95% CI: \u22120.39, \u22120.27). Response surfaces revealed that lower proportional energy from protein, diluted by high fat and\/or carbohydrate, was associated with higher total energy intake and greater 12\u2010month increases in body weight, WHtR, and HHtR, but not FMI. Consumption of discretionary food, not other food sources, increased energy intake by reducing proportional energy from protein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maintaining dietary proportional energy from protein, particularly by limiting discretionary food consumption, was associated with reduced energy intake and improved WLM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.24370","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T23:30:18Z","timestamp":1754609418000},"page":"1995-2004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dietary Macronutrient Composition and Protein Concentration for Weight Loss Maintenance"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1947-3310","authenticated-orcid":false,"given":"Hanyue","family":"Zhang","sequence":"first","affiliation":[{"name":"Research Unit for Diet and Health The Parker Institute, Bispebjerg and Frederiksberg Hospital  Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterina","family":"Vasileiou","sequence":"additional","affiliation":[{"name":"Department of Food Science University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Searle","sequence":"additional","affiliation":[{"name":"Center for Clinical Research and Prevention Bispebjerg and Frederiksberg Hospital  Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofus C.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Research Unit for Diet and Health The Parker Institute, Bispebjerg and Frederiksberg Hospital  Frederiksberg Denmark"},{"name":"Section for General Practice, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair M.","family":"Senior","sequence":"additional","affiliation":[{"name":"Charles Perkins Centre University of Sydney  Sydney New South Wales Australia"},{"name":"School of Life and Environmental Sciences University of Sydney  Sydney New South Wales Australia"},{"name":"Sydney Precision Data Science Centre University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faidon","family":"Magkos","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh C.","family":"Ward","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Horgan","sequence":"additional","affiliation":[{"name":"Biomathematics and Statistics Scotland, BioSS  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Nutri\u00e7\u00e3o, Faculdade de Medicina, Centro Acad\u00e9mico de Medicina de Lisboa Universidade de Lisboa  Lisbon Portugal"},{"name":"Instituto de Sa\u00fade Ambiental (ISAMB), Faculdade de Medicina Universidade de Lisboa  Lisbon Portugal"},{"name":"CIDEFES, Universidade Lus\u00f3fona &amp; CIFI2D, Universidade do Porto  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio L.","family":"Palmeira","sequence":"additional","affiliation":[{"name":"CIDEFES, Universidade Lus\u00f3fona &amp; CIFI2D, Universidade do Porto  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0256-7687","authenticated-orcid":false,"given":"Stephen J.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Charles Perkins Centre University of Sydney  Sydney New South Wales Australia"},{"name":"School of Life and Environmental Sciences University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Raubenheimer","sequence":"additional","affiliation":[{"name":"Charles Perkins Centre University of Sydney  Sydney New South Wales Australia"},{"name":"School of Life and Environmental Sciences University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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