{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T05:16:02Z","timestamp":1773551762524,"version":"3.50.1"},"reference-count":69,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK134646"],"award-info":[{"award-number":["R01DK134646"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK123181"],"award-info":[{"award-number":["R01DK123181"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19KK0402"],"award-info":[{"award-number":["19KK0402"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Vertical sleeve gastrectomy (VSG) promotes significant metabolic improvements, though the underlying molecular mechanisms are not fully understood. Emerging evidence suggests that small extracellular vesicles (sEVs) contribute to metabolic improvements post VSG, such as improved fatty liver disease or adipose tissue function; however, it is unclear how different organ\u2010specific sEVs interact with various metabolic parameters. The objective of this study is to establish the role of organ\u2010specific sEVs in the metabolic improvements post VSG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Demographic and anthropometric data, metabolic parameters, and sEV samples were collected pre VSG and 3\u20136 months post VSG in youth with obesity. sEV RNA was sequenced for bioinformatics analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significant reduction of the liver\u2010enriched mRNA cargo in sEVs was observed post VSG, whereas adipose\u2010enriched mRNA cargo showed no such reduction. Liver\u2010enriched mRNA cargo correlated with BMI, leptin, and resistin 6 months post VSG. Analysis of delta values (post minus pre surgery) revealed that adipose\u2010enriched mRNA cargo correlated with markers of liver damage, whereas liver\u2010derived mRNA cargo correlated with branched\u2010chain amino acids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Following VSG, significant changes occur in the liver\u2010enriched mRNA cargo of sEVs. Liver\u2010derived sEVs appear to influence adipose metabolism, whereas adipose\u2010derived sEVs are linked with liver function, suggesting dynamic intertissue cross talk that shapes systemic metabolic outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70027","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T04:16:57Z","timestamp":1757564217000},"page":"2181-2194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring Organ\u2010Specific Extracellular Vesicles in Metabolic Improvements Following Bariatric Surgery in\u00a0Youth With Obesity"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2620-5501","authenticated-orcid":false,"given":"Ahlee","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Diabetes and Endocrinology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio 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