{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:51:21Z","timestamp":1790369481467,"version":"4.1.0"},"reference-count":86,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Obesity affects 42% of older adults, with rates continuing to rise. This a complex condition influenced by non\u2010modifiable as well as modifiable risk factors. The disease can be treated through modifications to diet, physical activity, and behavior and more recently through antiobesity medications (AOMs) and surgery. Treatment must be tailored to individual needs due to age\u2010related metabolic and physiological changes. This review aimed to identify the suitability of seven FDA\u2010approved AOMs in the treatment of obesity in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A review of AOMs was performed, focusing on their efficacy in weight loss, side effects, and potential health risks in older adults. Studies were selected to later evaluate the overall suitability and safety of these medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AOMs can improve cardiovascular outcomes, hypertension, hyperlipidemia, metabolic liver disease, obstructive sleep apnea, and chronic kidney disease. Weight loss in older adults using AOMs is associated with an increased risk of sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>From a policy standpoint, ensuring coverage of AOMs for older adults is critical, as these medications help reduce obesity\u2010related complications. However, increased participation in clinical trials is urgently needed to study the impact of quality of life and outcomes in older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70029","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T02:13:15Z","timestamp":1759975995000},"page":"57-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antiobesity Medications for Older Adults\u2014the New, the\u00a0Good, the Bad, and the Unknown"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0114-1342","authenticated-orcid":false,"given":"Anna","family":"Pendrey","sequence":"first","affiliation":[{"name":"Department of Family Medicine Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Sevilla\u2010Martir","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12551"},{"key":"e_1_2_10_3_1","volume-title":"The Chronic Disease of Obesity","author":"Batsis J.","year":"2023"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010016\u20109884\u20103"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2017.08.007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gnx128"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP161365.GL"},{"key":"e_1_2_10_8_1","unstructured":"\u201cReport: Adults 50 and Older Need More Physical Activity \u201d Centers for Disease Control and Prevention published April 232024 https:\/\/www.cdc.gov\/physical\u2010activity\/php\/reports\/adults\u201050\u2010and\u2010older.html."},{"key":"e_1_2_10_9_1","unstructured":"L.Perreault C. 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