{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:36:41Z","timestamp":1784349401045,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","award":["23\/0006598"],"award-info":[{"award-number":["23\/0006598"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Fatty acids in adipose tissue are key structural and metabolic regulators of cardiometabolic health, but the genetic architecture governing depot\u2010specific composition in subcutaneous (SAT) and visceral adipose tissue (VAT) is not well defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used MRI\u2010derived estimates of fatty acid composition in SAT and VAT from 33,583 UK Biobank participants to perform genome\u2010wide association studies. Functional annotation, fine mapping, colocalization, and expression QTL analyses were conducted to prioritize likely causal variants and explore mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified six loci associated with adipose tissue fatty acid composition, including both shared (\n                      <jats:italic>PKD2L1<\/jats:italic>\n                      ,\n                      <jats:italic>INSIG1<\/jats:italic>\n                      ) and depot\u2010specific associations (\n                      <jats:italic>LEKR1<\/jats:italic>\n                      and\n                      <jats:italic>KLF14<\/jats:italic>\n                      for SAT;\n                      <jats:italic>CDCA2<\/jats:italic>\n                      for VAT). The strongest association, rs603424\u2010G (near\n                      <jats:italic>PKD2L1<\/jats:italic>\n                      ), was linked to higher monounsaturated and polyunsaturated fatty acids, lower saturated fatty acids, and increased\n                      <jats:italic>SCD1<\/jats:italic>\n                      expression in SAT and VAT, suggesting a role in desaturation and lipid remodeling. Several loci were linked to cardiometabolic outcomes including type 2 diabetes, hypertension, and cholelithiasis, with functional evidence supporting gene\u2013diet interactions at the\n                      <jats:italic>PKD2L1<\/jats:italic>\n                      locus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings uncover genetic determinants of human adipose tissue fatty acid composition, highlight depot\u2010specific regulation, and point to\n                      <jats:italic>SCD1<\/jats:italic>\n                      as a potential metabolic regulator. These results deepen understanding of lipid metabolism and its links to cardiometabolic risk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70045","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T05:36:31Z","timestamp":1759210591000},"page":"2406-2415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic Determinants of Fatty Acid Composition in\u00a0Subcutaneous and Visceral Adipose Tissue"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4748-1991","authenticated-orcid":false,"given":"Altayeb","family":"Ahmed","sequence":"first","affiliation":[{"name":"School of Natural Sciences, College of Health and Science University of Lincoln, Joseph Banks Laboratories  Lincoln UK"},{"name":"School of Human Development and Health, Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8218-5584","authenticated-orcid":false,"given":"Afreen","family":"Naz","sequence":"additional","affiliation":[{"name":"School of Natural Sciences, College of Health and Science University of Lincoln, Joseph Banks Laboratories  Lincoln UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1789-7112","authenticated-orcid":false,"given":"Marjola","family":"Thanaj","sequence":"additional","affiliation":[{"name":"Research Centre for Optimal Health, School of Life Sciences University of Westminster  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena P.","family":"Sorokin","sequence":"additional","affiliation":[{"name":"Calico Life Sciences LLC  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Whitcher","sequence":"additional","affiliation":[{"name":"Research Centre for Optimal Health, School of Life Sciences University of Westminster  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy D.","family":"Bell","sequence":"additional","affiliation":[{"name":"Research Centre for Optimal Health, School of Life Sciences University of Westminster  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4235-4694","authenticated-orcid":false,"given":"E. Louise","family":"Thomas","sequence":"additional","affiliation":[{"name":"Research Centre for Optimal Health, School of Life Sciences University of Westminster  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Cule","sequence":"additional","affiliation":[{"name":"Calico Life Sciences LLC  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanieh","family":"Yaghootkar","sequence":"additional","affiliation":[{"name":"School of Natural Sciences, College of Health and Science University of Lincoln, Joseph Banks Laboratories  Lincoln UK"},{"name":"School of Human Development and Health, Faculty of Medicine University of Southampton  Southampton 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