{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:54:50Z","timestamp":1778500490263,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019706","name":"Qatar Biomedical Research Institute, Hamad Bin Khalifa University","doi-asserted-by":"publisher","award":["IGP\u20101\u20102014\u2010001"],"award-info":[{"award-number":["IGP\u20101\u20102014\u2010001"]}],"id":[{"id":"10.13039\/100019706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007458","name":"Qatar Foundation","doi-asserted-by":"publisher","award":["NRPR11A\u20100102\u201018017"],"award-info":[{"award-number":["NRPR11A\u20100102\u201018017"]}],"id":[{"id":"10.13039\/100007458","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["B1\u20100028"],"award-info":[{"award-number":["B1\u20100028"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>DNAJB3, a heat shock protein, plays a critical role in metabolic aberrations associated with obesity and type 2 diabetes (T2D). This study investigated how DNAJB3 deficiency exacerbates inflammation and glucose intolerance in diet\u2010induced obese mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male and female DNAJB3 knockout (KO) and wild\u2010type (WT) mice were fed high\u2010sucrose (17\u2009kcal%) and high\u2010fat (HF: 45\u2009kcal%) or low\u2010fat (LF: 10\u2009kcal%) diets for 12\u2009weeks. Body weight, food intake, glucose tolerance, and energy expenditure were assessed; blood, adipose, and liver tissues were collected for histological and gene expression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HF\u2010fed KO females exhibited higher body and fat mass and lower glucose clearance and energy expenditure, compared to other groups. Males showed a clear HF diet effect across both genotypes. Increased serum leptin, interleukin 6, and insulin levels were observed in HF\u2010KO females, while HF\u2010KO males showed higher leptin and resistin levels compared to other groups. Additionally, inflammatory and glucose transporter gene expression was altered by DNAJB3 deficiency in adipose tissues and the pancreas, highlighting the impaired glucose metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest the importance of DNAJB3 in glucose and metabolic regulation, especially in females, and its potential use as a therapeutic target for obesity and T2D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70063","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:27:53Z","timestamp":1763015273000},"page":"138-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>DNAJB3<\/scp>\n                    Deficiency in Mice, Sex\u2010Dependently, Exacerbates High\u2010Fat Diet\u2010Induced Metabolic Dysfunctions"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5666-9000","authenticated-orcid":false,"given":"Shadi","family":"Nejat","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences Texas Tech University  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalhara R.","family":"Menikdiwela","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Texas Tech University  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Iskander","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Texas Tech University  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haley","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Texas Tech University  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane","family":"Scoggin","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Texas Tech University  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Yosofvand","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Texas Tech University  Lubbock Texas USA"},{"name":"Department of Mechanical Engineering Texas Tech University  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0668-3442","authenticated-orcid":false,"given":"Hanna","family":"Moussa","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Texas Tech University  Lubbock Texas USA"},{"name":"Department of Physics and Astronomy Texas Tech University  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiao","family":"Zu","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Texas Tech University  Lubbock Texas USA"},{"name":"Institute for One Health Innovation &amp; Center of Excelence in Obesity and Cardiometabolic Research Texas Tech University and Texas Tech University Health Sciences Center  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannette M.","family":"Dufour","sequence":"additional","affiliation":[{"name":"Institute for One Health Innovation &amp; Center of Excelence in Obesity and Cardiometabolic Research Texas Tech University and Texas Tech University Health Sciences Center  Lubbock Texas USA"},{"name":"Department of Cell Biology &amp; Biochemistry, School of Medicine Texas Tech University Health Sciences Center  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4987-2646","authenticated-orcid":false,"given":"Anand","family":"Chakroborty","sequence":"additional","affiliation":[{"name":"Department of Cell Biology &amp; Biochemistry, School of Medicine Texas Tech University Health Sciences Center  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bolormaa","family":"Vandanmagsar","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, LSU System  Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Thornalley","sequence":"additional","affiliation":[{"name":"Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University  Doha Qatar"},{"name":"College of Health &amp; 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