{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:05:29Z","timestamp":1791644729390,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM201801060"],"award-info":[{"award-number":["SZSM201801060"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to compare the effectiveness and safety of semaglutide 1.0\u2009mg versus dulaglutide 1.5\u2009mg and liraglutide 1.8\u2009mg in patients with type 2 diabetes mellitus (T2DM) under routine clinical care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, retrospective, real\u2010world study enrolled Chinese adults with T2DM who initiated GLP\u20101 receptor agonist therapy in endocrinology clinics between January 1, 2022, and August 31, 2024. We compared the effectiveness of these agents on HbA1c and weight loss, with safety as a key exploratory endpoint. Additionally, the UK Prospective Diabetes Study Outcomes Model 2.1 was utilized to project long\u2010term health outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This multicenter retrospective study included 111, 74, and 107 patients treated with semaglutide 1.0\u2009mg, dulaglutide 1.5\u2009mg, and liraglutide 1.8\u2009mg, respectively. After 1:1 propensity score matching, semaglutide demonstrated significantly greater HbA1c reduction compared to both dulaglutide (\u22120.27%\u2009\u00b1\u20090.70%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) and liraglutide (\u22120.39%\u2009\u00b1\u20090.87%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), along with higher glycemic target achievement rates. Semaglutide was associated with improved outcomes in all death, cardiovascular death, and other death endpoints. No significant differences in safety profiles were observed among the three treatment groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Semaglutide demonstrated superior glycemic control and weight loss compared to both dulaglutide and liraglutide, whereas dulaglutide and liraglutide exhibited comparable clinical efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70065","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T04:06:48Z","timestamp":1763698008000},"page":"101-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Semaglutide Versus Dulaglutide and Liraglutide in Chinese Patients With\n                    <scp>T2DM<\/scp>\n                    : A Multicenter Real\u2010World Study"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1609-4377","authenticated-orcid":false,"given":"Zeyu","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Shenzhen Baoan People's Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiling","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Specialty of Clinical Pharmacy The First Affiliated Hospital of Guangdong Pharmaceutical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1062903"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.22208"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"issue":"24","key":"e_1_2_11_5_1","first-page":"2868","article-title":"Comprehensive Clinical Evaluation of Six Glucagon\u2010Like Peptide\u20101 Receptor Agonists for Type 2 Diabetes Mellitus","volume":"44","author":"Xie Z.","year":"2024","journal-title":"Chinese 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