{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:05:00Z","timestamp":1791338700267,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UH3HL155801"],"award-info":[{"award-number":["UH3HL155801"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U24HL155802"],"award-info":[{"award-number":["U24HL155802"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study aimed to apply\n                      <jats:italic>The Lancet Diabetes &amp; Endocrinology<\/jats:italic>\n                      criteria for diagnosing obesity among clinical trial participants and understand participants' characteristics by obesity status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The criteria were operationalized and applied to baseline data from the Long\u2010term Effectiveness of the Anti\u2010obesity medication Phentermine (LEAP) trial (NCT05176626). Excess adiposity, organ and tissue dysfunction, and limitations to daily activities were assessed. We examined differences between participants with \u201cno obesity,\u201d \u201cpre\u2010clinical obesity,\u201d and \u201cclinical obesity.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 860 participants, 0.8% had no obesity (mean BMI 29.0\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      [SD 0.6]), 18.7% had pre\u2010clinical obesity (mean BMI 35.2\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      [SD 3.5]), and 80.5% had clinical obesity (mean BMI 35.9\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      [SD 4.3]). Participants with no\/pre\u2010clinical obesity had lower mean SF\u201012 mental component scores and greater baseline engagement with weight control strategies compared to those with clinical obesity. Participants with clinical obesity were older and, by definition, had a greater burden of cardiometabolic risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among clinical trial participants eligible for obesity pharmacotherapy, 19.5% were classified as having no\/pre\u2010clinical obesity using the Lancet criteria. Applying the criteria was complicated in a well\u2010resourced trial setting, which suggests potential challenges in implementing these guidelines in real\u2010world practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70070","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:03:12Z","timestamp":1761656592000},"page":"58-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Application of the Lancet Commission Criteria for the Diagnosis of Obesity to a Clinical Trials Population: The\n                    <scp>LEAP<\/scp>\n                    Trial"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6819-8258","authenticated-orcid":false,"given":"Faith Anne N.","family":"Heeren","sequence":"first","affiliation":[{"name":"Department of Implementation Science Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5721-1874","authenticated-orcid":false,"given":"Kathleen R.","family":"Ruddiman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Endocrinology Section Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3613-2377","authenticated-orcid":false,"given":"Courtney","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian N.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron C.","family":"Jaeger","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Pajewski","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4222-7046","authenticated-orcid":false,"given":"Stephanie A.","family":"Hooker","sequence":"additional","affiliation":[{"name":"HealthPartners Institute  Minneapolis Minnesota USA"},{"name":"Department of Family Medicine and Community Health University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah B.","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Texas McGovern Medical School  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy","family":"Martin\u2010Fernandez","sequence":"additional","affiliation":[{"name":"Atrium Health Wake Forest Baptist, Weight Management Center  Winston\u2010Salem North Carolina USA"},{"name":"Department of Surgery Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7782-1769","authenticated-orcid":false,"given":"Kimberly A.","family":"Gudzune","sequence":"additional","affiliation":[{"name":"American Board of Obesity Medicine Foundation  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Blackwell","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamy","family":"Ard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Endocrinology Section Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"},{"name":"Department of Epidemiology and Prevention Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-7230","authenticated-orcid":false,"given":"Kristina Henderson","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Implementation Science Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"},{"name":"Department of Epidemiology and Prevention Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(24)00316-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.2704"},{"key":"e_1_2_10_4_1","unstructured":"Centers for Disease Control and Prevention \u201cNational Health and Nutrition Examination Survey (NHANES) Anthropometry Procedures: Centers for Disease Control and Prevention \u201d2007."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774514537404"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199603000-00003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20368"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eatbeh.2012.03.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521729"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1801"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.07.018"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12266"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.09.019"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.35"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371205700103"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2011.03.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-018-0858-2"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16389"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(25)00229-3"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003072"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.70070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.70070","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.70070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T10:19:24Z","timestamp":1771323564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.70070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,27]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/oby.70070"],"URL":"https:\/\/doi.org\/10.1002\/oby.70070","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,27]]},"assertion":[{"value":"2025-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}