{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:18:57Z","timestamp":1775845137729,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study examined associations between CDC's 2022 extended BMI percentiles (BMIp) and cardiometabolic biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using electronic medical record data, we included patients aged 6\u201317\u2009years with BMI\u00a0\u2265\u200985th percentile who had at least one of the following: total cholesterol, low\u2010density lipoprotein cholesterol (LDL), high\u2010density lipoprotein cholesterol (HDL), triglycerides, alanine aminotransferase (ALT), and hemoglobin A1c (HbA1c). We calculated adjusted prevalence ratios (aPR) for (1) borderline or abnormal and (2) abnormal lab values by extended BMIp (85th\u2013&lt;\u200995th, 95th\u2013&lt;\u200998th, 98th\u2013&lt;\u200999th, 99th\u2013&lt;\u200999.9th, \u2265\u200999.9th).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to those with overweight (BMIp 85th\u2013&lt;\u200995th), patients in higher extended BMIp categories had a higher prevalence of borderline or abnormal HbA1c (aPR range: 1.46\u20132.79), ALT (aPR range: 1.58\u20132.59), triglycerides (aPR range: 1.24\u20131.46), total cholesterol (aPR range: 1.11\u20131.23), HDL (aPR range: 1.40\u20131.94), and LDL (aPR range: 1.23\u20131.55). Dose\u2013response relationships were observed for multiple cardiometabolic biomarkers. Similar patterns were found for abnormal lab values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Many US youth aged 6\u201317 with overweight and obesity had borderline or abnormal cardiometabolic biomarkers. Risks varied within obesity: higher extended BMIp were linked to a greater likelihood of borderline or abnormal lab values. Identifying extended BMIp thresholds tied to these risks could facilitate clinical practice, including identifying high\u2010risk patients and informing escalation of care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70077","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T06:15:36Z","timestamp":1766384136000},"page":"450-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Examining Biomarkers for Dyslipidemia, Diabetes, and\n                    <scp>NAFLD<\/scp>\n                    by CDC's 2022 Extended\n                    <scp>BMI<\/scp>\n                    Percentiles in\n                    <scp>US<\/scp>\n                    Youth Aged 6\u201317\u2009Years"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8193-1848","authenticated-orcid":false,"given":"Samantha L.","family":"Pierce","sequence":"first","affiliation":[{"name":"Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee M.","family":"Porter","sequence":"additional","affiliation":[{"name":"Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0634-689X","authenticated-orcid":false,"given":"Lyudmyla","family":"Kompaniyets","sequence":"additional","affiliation":[{"name":"Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siran","family":"He","sequence":"additional","affiliation":[{"name":"Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyson B.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention  Atlanta Georgia USA"},{"name":"United States Public Health Service Commissioned Corps  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,21]]},"reference":[{"issue":"41","key":"e_1_2_11_2_1","article-title":"Quickstats: Trends in Prevalence of Obesity and Severe Obesity Among Children and Adolescents Ages 2\u201319\u2009Years \u2014 United States, 1999\u20132000 Through August 2021\u2013August 2023","volume":"73","author":"National Center for Health Statistics","year":"2024","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_11_3_1","volume-title":"Prevalence of Overweight, Obesity, and Severe Obesity Among Children and Adolescents Aged 2\u201319\u2009Years: United States, 1963\u20131965 Through 2017\u20132018","author":"Fryar C. 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