{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:51:12Z","timestamp":1790369472617,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This meta\u2010analysis evaluates the safety and efficacy of glucagon\u2010like peptide\u20101 receptor agonists\u00a0(GLP\u20101 RA) for the treatment of older adults with obesity compared to younger individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted following PRISMA guidelines (PROSPERO CRD420251074381). PubMed, Embase, and Scopus were searched until May 17, 2025, for randomized controlled trials and observational studies assessing GLP\u20101 RA in adults \u2265\u200965\u2009years with obesity with or without type 2 diabetes. Random effects meta\u2010analyses calculated the log odds ratios (LOR) for dichotomous outcomes and the mean differences (MD) for continuous outcomes, with equivalence testing via two one\u2010sided tests (TOST) and meta\u2010regression for baseline adjustments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five studies involving 1229 participants were included. No significant difference in serious adverse events was found between older and younger adults (pooled LOR: 0.06,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.9). Older adults had a trend toward lower frequency of nausea (LOR: \u22120.44,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06) but higher incidence of constipation (LOR: 0.72,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and hypoglycemia (LOR: 0.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Efficacy in metabolic and weight control was comparable. Additionally, one study suggested that liraglutide could reduce fat mass without worsening sarcopenia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101 RA therapy seems to be safe and effective in older adults with obesity, achieving similar effects on weight loss and glycemic control as in younger individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70098","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:30:55Z","timestamp":1770273055000},"page":"25-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Safety and Efficacy of Glucagon\u2010Like Peptide\u20101 Receptor Agonists\u00a0Use in Elderly People With Obesity\u2014A Meta\u2010Analysis"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6492-7185","authenticated-orcid":false,"given":"In\u00eas","family":"Rego de Figueiredo","sequence":"first","affiliation":[{"name":"Multidisciplinary Unit of Bariatric and Metabolic Surgery, Curry Cabral Hospital, Unidade Local de Sa\u00fade S\u00e3o Jos\u00e9, Centro Cl\u00ednico Acad\u00e9mico de Lisboa  Lisbon Portugal"},{"name":"Egas Moniz School of Health and Science  Almada Portugal"},{"name":"NOVA Medical School\/Faculdade de Ciencias Medicas New University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipa Sofia","family":"Simas","sequence":"additional","affiliation":[{"name":"Multidisciplinary Unit of Bariatric and Metabolic Surgery, Curry Cabral Hospital, Unidade Local de Sa\u00fade S\u00e3o Jos\u00e9, Centro Cl\u00ednico Acad\u00e9mico de Lisboa  Lisbon Portugal"},{"name":"Department of Nutrition Curry Cabral Hospital, Unidade Local de Sa\u00fade S\u00e3o Jos\u00e9, Centro Cl\u00ednico Acad\u00e9mico de Lisboa  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Ghiletchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Garcia de Orta, Unidade Local de Sa\u00fade Almada\u2010Seixal  Almada Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Oliveira Torres","sequence":"additional","affiliation":[{"name":"Multidisciplinary Unit of Bariatric and Metabolic Surgery, Curry Cabral Hospital, Unidade Local de Sa\u00fade S\u00e3o Jos\u00e9, Centro Cl\u00ednico Acad\u00e9mico de Lisboa  Lisbon Portugal"},{"name":"NOVA Medical School\/Faculdade de Ciencias Medicas New University of Lisbon  Lisbon Portugal"},{"name":"Department of Endocrinology, Diabetes, and Metabolism Curry Cabral Hospital, Unidade Local de Sa\u00fade S\u00e3o Jos\u00e9, Centro Cl\u00ednico Acad\u00e9mico de Lisboa  Lisbon Portugal"},{"name":"Faculdade de Medicina Universidade de Lisboa  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Silva\u2010Nunes","sequence":"additional","affiliation":[{"name":"Multidisciplinary Unit of Bariatric and Metabolic Surgery, Curry Cabral Hospital, Unidade Local de Sa\u00fade S\u00e3o Jos\u00e9, Centro Cl\u00ednico Acad\u00e9mico de Lisboa  Lisbon Portugal"},{"name":"NOVA Medical School\/Faculdade de Ciencias Medicas New University of Lisbon  Lisbon Portugal"},{"name":"Department of Endocrinology, Diabetes, and Metabolism Curry Cabral Hospital, Unidade Local de Sa\u00fade S\u00e3o Jos\u00e9, Centro Cl\u00ednico Acad\u00e9mico de Lisboa  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-024-01529-z"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaa231"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121993"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3608-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100038\u20101674366"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13331"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02996-7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ16-0428"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14469"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13773"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2025.01.002"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-015-0525-y"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.70098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.70098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.70098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:25:38Z","timestamp":1788337538000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.70098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":16,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/oby.70098"],"URL":"https:\/\/doi.org\/10.1002\/oby.70098","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]},"assertion":[{"value":"2025-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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