{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:23:15Z","timestamp":1786551795389,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007152","name":"Vivus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007152","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study compared\u00a0the effects of phentermine\u2010topiramate\u2010ER (mid\u2010dose 7.5\/46\u2009mg) versus placebo on weight loss and cardiovascular disease (CVD) risk outcomes when used as an adjunct to a digitally enhanced lifestyle intervention (DELI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a 12\u2010month, randomized, double\u2010blind, placebo\u2010controlled trial at a single tertiary academic center in the United States (June 2020\u2013June 2022). Eighty participants with obesity (BMI \u2265\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) were enrolled in the DELI program, consisting of in\u2010person and telehealth modalities, dietary and physical activity goals, and use of a smartphone application integrated with digital devices (Apple Watch and Bluetooth\u2010enabled weight scale and blood pressure monitor). Participants were randomized 1:1 to receive either phentermine\u2010topiramate\u2010ER (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200942) or placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200938) in addition to the DELI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 3\u2009months, the phentermine\u2010topiramate group lost a mean of 10.82\u2009kg versus 4.04\u2009kg in the placebo group (mean difference \u22126.78\u2009kg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). At 12\u2009months, weight loss was 15.32\u2009kg versus 5.85\u2009kg, respectively (mean difference \u22129.48\u2009kg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Participants receiving phentermine\u2010topiramate\u2010ER experienced a 3.35% reduction in the estimated atherosclerotic CVD risk compared to baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Phentermine\u2010topiramate\u2010ER, when combined with a DELI, produced significant and sustained weight loss and reduced CVD risk in adults with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      : NCT04408586\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70108","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T12:13:45Z","timestamp":1768997625000},"page":"524-536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Addition of Phentermine\u2010Topiramate to a Digitally Enhanced Lifestyle Intervention: A Double\u2010Blind Randomized Clinical Trial"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-8652","authenticated-orcid":false,"given":"Alejandro","family":"Campos","sequence":"first","affiliation":[{"name":"Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-6795","authenticated-orcid":false,"given":"Wissam","family":"Ghusn","sequence":"additional","affiliation":[{"name":"Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizeth","family":"Cifuentes","sequence":"additional","affiliation":[{"name":"Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sacoto","sequence":"additional","affiliation":[{"name":"Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Fansa","sequence":"additional","affiliation":[{"name":"Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1829-7001","authenticated-orcid":false,"given":"Diego","family":"Anazco","sequence":"additional","affiliation":[{"name":"Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L.","family":"Ricardo\u2010Silgado","sequence":"additional","affiliation":[{"name":"Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Hashem","sequence":"additional","affiliation":[{"name":"Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Harmsen","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics &amp; 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