{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:30:15Z","timestamp":1790328615817,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to assess weight and safety outcomes in a large national cohort of patients with overweight and obesity treated with GLP\u20101 medications via telehealth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were obtained from deidentified EHRs for a random sample of 4500 patients who initiated semaglutide treatment via telehealth for overweight and obesity between December 1, 2022, and June 1, 2023. Outcomes and predictors of outcomes were analyzed for patients who reported a follow\u2010up weight within \u00b114\u2009days of week 68.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 655 patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009445 female,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009210 male), mean body weight reduction was \u221216.6% (SD 7.5%, 95% CI: \u221217.1% to \u221216.0%). Female sex was the only factor consistently associated with categorical weight loss, with significantly higher odds at \u2265\u20095% (OR\u00a04.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), \u2265\u200910% (OR 5.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and \u2265\u200920% (OR 2.51,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The most common adverse events were nausea\/vomiting (37.3%) and constipation (15.6%); no new safety signals were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings suggest semaglutide treatment via telehealth can achieve trial\u2010level weight loss with similar safety profiles, supporting telehealth as an evidence\u2010based approach to medical weight management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70120","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:01:11Z","timestamp":1765353671000},"page":"729-737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Real\u2010World Evidence on Weight Loss and Safety With Semaglutide in Obesity Telehealth: A Large Retrospective Cohort Study"],"prefix":"10.1002","volume":"34","author":[{"given":"Beverly","family":"Tchang","sequence":"first","affiliation":[{"name":"Comprehensive Weight Control Center, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine Weill Cornell Medicine  New York New York USA"},{"name":"Roman Health Ventures  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0048-4474","authenticated-orcid":false,"given":"Lauren","family":"Broffman","sequence":"additional","affiliation":[{"name":"Roman Health Ventures  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Manalac","sequence":"additional","affiliation":[{"name":"Roman Health Ventures  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Chai","sequence":"additional","affiliation":[{"name":"Roman Health Ventures  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Samonas","sequence":"additional","affiliation":[{"name":"Roman Health Ventures  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melynda","family":"Barnes","sequence":"additional","affiliation":[{"name":"Roman Health Ventures  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Allison","sequence":"additional","affiliation":[{"name":"Roman Health Ventures  New York New York USA"},{"name":"USDA\u2010ARS Children's Nutrition Research Center, Baylor College of Medicine, and Texas Children\u2019s Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.102108"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15924"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24331"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010023\u201001456\u20105"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.70036"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.33326"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.2525"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010025\u201007712\u2010z"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22173"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.208"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22054"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/tmr.2024.0031"},{"key":"e_1_2_10_15_1","article-title":"Where Are Patients Getting Their Prescriptions for GLP\u20101 Drugs Like Wegovy and Ozempic?","author":"Palmer K.","journal-title":"STAT News"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1977.10489493"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.0015"},{"key":"e_1_2_10_18_1","first-page":"1","article-title":"Obesity and Severe Obesity Prevalence in Adults: United States, August 2021\u2013August 2023","volume":"508","author":"Emmerich S. 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