{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:38:13Z","timestamp":1790609893608,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The effects of metabolic and bariatric surgery on bone health still require further investigation. Osteometabolism biomarkers, bone microarchitecture (BM), and mineral density (BMD) of patients who have undergone Roux\u2010en\u2010Y gastric bypass (RYGB) within 2\u20135\u2009years from surgery were compared to non\u2010surgical age\u2010, sex\u2010, and BMI\u2010matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This cross\u2010sectional study included 39 patients following RYGB (BG: aged\u2009=\u200939\u2009\u00b1\u20095\u2009years, BMI\u2009=\u200942.2\u2009\u00b1\u20093.8\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and 21 controls (CG). Circulating levels of albumin, calcium, phosphorus, magnesium, 25(OH) vitamin D, parathyroid hormone (PTH), carboxy\u2010terminal telopeptide of type 1 collagen (CTX\u20101), and amino\u2010terminal propeptide of type 1 procollagen (P1NP) were assayed. BMD and BM were assessed by dual\u2010energy X\u2010ray absorptiometry (DXA) and three\u2010dimensional high\u2010resolution peripheral quantitative computed tomography system (HR\u2010pQCT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BG presented with higher circulating phosphorus, PTH, CTX\u20101, and P1NP and lower 25(OH) vitamin D compared to CG. DXA parameters did not differ between groups. However, HR\u2010pQCT revealed significant derangements in BM (trabecular thickness, cortical bone density, and outer trabecular volumetric BMD) in BG. BG showed tibia\u2010specific trabecular microarchitecture impairment, while sex and BMI showed the expected associations with BM measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RYGB was associated with detrimental effects on osteometabolism biomarkers, as well as on density and structural parameters of BM. Early preventive strategies aimed at mitigating these deleterious effects should be systematically evaluated to minimize their long\u2010term impact.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      (NCT04193397)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70132","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:25:34Z","timestamp":1771395934000},"page":"598-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bone Health After Metabolic and Bariatric Surgery: Osteometabolism Biomarkers, Bone Mineral Density, and Microarchitecture"],"prefix":"10.1002","volume":"34","author":[{"given":"Camila Medeiros","family":"de Almeida","sequence":"first","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental Physiopathology, Faculty of Medical Sciences State University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Obesity Unit, Multiuser Clinical Research Center (CePeM), Hospital Universit\u00e1rio Pedro Ernesto State University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3005-3889","authenticated-orcid":false,"given":"Karynne Grutter","family":"Lopes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental Physiopathology, Faculty of Medical Sciences State University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Obesity Unit, Multiuser Clinical Research Center (CePeM), Hospital Universit\u00e1rio Pedro Ernesto State University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Department of Physiological Sciences, Roberto Alcantara Gomes Institute of Biology State University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"da Costa Tavares Bezerra","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental Physiopathology, Faculty of Medical Sciences State University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Obesity Unit, Multiuser Clinical Research Center (CePeM), Hospital Universit\u00e1rio Pedro Ernesto State University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Roberto Falc\u00e3o","family":"Leal","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental Physiopathology, Faculty of Medical Sciences State University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Obesity Unit, Multiuser Clinical Research Center (CePeM), Hospital Universit\u00e1rio Pedro Ernesto State University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"General Surgery, Department of Surgery, Faculty of Medical Sciences State University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliete","family":"Bouskela","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Clinical and Experimental Physiopathology, Faculty of Medical Sciences State University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Obesity Unit, Multiuser Clinical Research Center (CePeM), Hospital Universit\u00e1rio Pedro Ernesto State University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Medeiros Ferreira","family":"da Gama","sequence":"additional","affiliation":[{"name":"Endocrinology Division Federal University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lucia 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