{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:54:14Z","timestamp":1790610854629,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate whether reduced\u2010frequency dosing of GLP1 receptor agonists maintains weight loss, body composition, and metabolic syndrome improvements following successful initial treatment with standard weekly therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective case series included 30 adults who achieved weight plateau while on weekly semaglutide or tirzepatide. Patients transitioned to reduced\u2010frequency dosing (usually every other week) at their existing dose. Data were collected at three time points: pre\u2010treatment, plateau (weekly dosing), and maintenance (reduced\u2010frequency dosing). Primary outcome was change in body weight from plateau to maintenance. Secondary outcomes included body composition and metabolic syndrome comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients maintained reduced\u2010frequency dosing for an average of 36.3\u2009weeks. Weight decreased from 87.9\u2009\u00b1\u20092.4\u2009kg at pre\u2010treatment to 74.1\u2009\u00b1\u20092.4\u2009kg at plateau and further to 72.4\u2009\u00b1\u20092.2\u2009kg on maintenance dosing (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Total body and truncal fat declined, while skeletal muscle mass stabilized on the reduced\u2010frequency regimen. Metabolic parameters improved during weekly dosing and these gains were maintained during reduced\u2010frequency therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with prior weight loss and metabolic improvement on GLP1 therapy, reduced\u2010frequency maintenance dosing preserved outcomes. These findings support structured de\u2010escalation as a promising strategy to reduce treatment burden without sacrificing efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70137","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:13:49Z","timestamp":1772968429000},"page":"112-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Reduced\u2010Frequency\n                    <scp>GLP1<\/scp>\n                    Therapy Maintains Weight, Body Composition, and Metabolic Syndrome Improvements: A Case Series"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6209-7475","authenticated-orcid":false,"given":"Michelle","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Scripps Clinic  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ash","family":"Wu","sequence":"additional","affiliation":[{"name":"Samuel Merritt University  Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawanjot K.","family":"Garhe","sequence":"additional","affiliation":[{"name":"University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitch","family":"Biermann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Scripps Clinic  San Diego California USA"},{"name":"Scripps Whittier Diabetes Institute  San Diego California 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