{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:28:28Z","timestamp":1791570508377,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["20IPA35260142"],"award-info":[{"award-number":["20IPA35260142"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["F31HL165967\u201001A1"],"award-info":[{"award-number":["F31HL165967\u201001A1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011866","name":"Colorado Clinical and Translational Sciences Institute","doi-asserted-by":"publisher","award":["TL1TR002533\u201005"],"award-info":[{"award-number":["TL1TR002533\u201005"]}],"id":[{"id":"10.13039\/100011866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluated impacts of vertical sleeve gastrectomy (VSG) on glycemic and cardiometabolic outcomes in youth\u2010onset type 2 diabetes (YO\u2010T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pre\u2010 and postoperative (3 and 12\u2009months) anthropometrics, mixed\u2010meal tolerance test (MMTT) and body composition assessments, and hyperglycemic clamps (preoperative and 12\u2009months postoperatively) were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Weight (\u221224.6\u2009\u00b1\u20095.2\u2009kg at 3\u2009months; \u221231.0\u2009\u00b1\u20095.2\u2009kg at 12\u2009months) and BMI (\u22128.5\u2009\u00b1\u20092.0\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; \u221210.8\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) fell by 18% and 23%, respectively (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Body fat decreased 6.4% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) at 12\u2009months, and fat mass by 16.8\u2009\u00b1\u20094.7\u2009kg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). MMTT\u2010stimulated GLP\u20101, PYY, insulin, and C\u2010peptide secretion increased and insulin clearance, glucose, HbA1c (6.6%\u2009\u00b1\u20090.2% to 5.7%\u2009\u00b1\u20090.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), free fatty acids (FFA), LDL, triglycerides, adipose\u2010focused Adipo\u2010IR, liver transaminases and hepatic\u2010predominant insulin sensitivity (Si) (HOMA\u2010IR) decreased at 3\u2009months post VSG. With maximal 12\u2010month weight loss, MMTT\u2010stimulated insulin, C\u2010peptide, and GLP\u20101 responses attenuated, insulin clearance increased, muscle\u2010predominant Si (hyperglycemic clamp M\/I, Matsuda index, static\/dynamic oral minimal modeling), \u03b2\u2010cell function, resting heart rate, systolic blood pressure, and HDL improved, and all 3\u2010month improvements persisted, with 86% of participants off diabetes medications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VSG in YO\u2010T2D produces rapid and sustained improvements in weight, body composition, cardiometabolic health, Si, FFA, \u03b2\u2010cell function, and glycemia, with most no longer needing diabetes medications.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov identifier: NCT03620773.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70140","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:45:15Z","timestamp":1771472715000},"page":"121-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Vertical Sleeve Gastrectomy in Youth\u2010Onset Type 2 Diabetes: Changes in Glycemia, Insulin Sensitivity, and Secretion"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2088-1370","authenticated-orcid":false,"given":"Tyler J.","family":"Dobbs","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Colorado Anschutz Medical Campus and Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pyle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Washington and Seattle Children's Hospital  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime M.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado Anschutz Medical Campus and Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Garrish","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics and Statistics Colorado School of Mines  Golden Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Diniz","family":"Behn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado Anschutz Medical Campus and Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Department of Applied Mathematics and Statistics Colorado School of Mines  Golden Colorado 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and Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4059-4283","authenticated-orcid":false,"given":"Carissa","family":"Birznieks","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado Anschutz Medical Campus and Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Melena","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado Anschutz Medical Campus and Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauryn","family":"Remmers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado Anschutz Medical Campus and Children's Hospital Colorado  Aurora Colorado 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