{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:34:17Z","timestamp":1784547257350,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This pilot study compared the effects of a calorie restricted diet (CRD) versus liraglutide on intrapancreatic fat deposition (IPFD) in people with obesity and explored associations between changes in adiposity\u2010related metrics and glycemic\u2010related parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this 24\u2010week prospective nonrandomized study, participants with obesity received CRD or liraglutide. Primary endpoint was the change in pancreatic fat fraction (PFF). Secondary endpoints included changes in body weight, liver fat fraction (LFF), visceral fat area (VFA), and glycemic\u2010related parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both CRD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923) and liraglutide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923) demonstrated significant and comparable reductions in PFF (time effect:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; interaction effect:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.560). Significant and similar improvements were also observed in body weight, LFF, VFA, HbA1c, HOMA2\u2010IR, and ISIM (all time effects:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; all interaction effects:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Regression analysis indicated that \u0394HOMA2\u2010IR was positively associated with \u0394weight and \u0394LFF but negatively with \u0394PFF, while \u0394ISIM was negatively associated with \u0394VFA and positively with \u0394PFF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both CRD and liraglutide significantly and similarly reduce pancreatic, liver, and visceral fat, while improving glycemic\u2010related parameters in people with obesity. Preliminary findings suggest liver and visceral fat loss primarily drive improved insulin resistance, whereas pancreatic fat reduction may relate to subtler insulin dynamics changes, warranting further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>This study is a sub\u2010study of the registered trial ChiCTR1900022948<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70153","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:35:10Z","timestamp":1772980510000},"page":"829-838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Calorie Restricted Diet Versus Liraglutide on Intrapancreatic Fat Deposition in People With Obesity: A\u00a0Pilot Study"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5085-095X","authenticated-orcid":false,"given":"Haiyan","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Shanghai Yangpu District Shidong Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center Nanjing Medical University  Wuxi 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