{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T07:56:07Z","timestamp":1775116567318,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Obesity is a major risk factor for multiple cancers, yet the impact of nonsurgical weight loss on cancer risk remains uncertain. Our objective was to evaluate whether real\u2010world nonsurgical weight loss is associated with a reduced risk of developing cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective observational study of 143,630 adults (BMI\u2009\u2265\u200930) from an integrated US health system's electronic health records (2000\u20132022). Cases with incident cancer were compared to matched controls. Using generalized linear models with a logit link, we assessed whether BMI change over 3\u2010, 5\u2010, and 10\u2010year intervals is associated with the risk of diagnosis for obesity\u2010related and other cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 143,630 patients, 7703 cases and 135,927 controls were identified. Each 1% BMI reduction was linked to lower obesity\u2010related cancer risk at 3\u2009years (OR, 0.990; 95% CI, 0.984\u20130.996;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), 5\u2009years (OR, 0.989; 95% CI, 0.984\u20130.995;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and 10\u2009years (OR, 0.992; 95% CI, 0.984\u20131.000;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.057). Similar associations were observed for other cancer types across all intervals (OR\u2009&lt;\u20091;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Real\u2010world weight loss was associated with a decreased risk of obesity\u2010related and other cancers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70163","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:30:01Z","timestamp":1773156601000},"page":"928-938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Weight Loss Is Associated With a Reduction in Cancer Risk"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9590-2557","authenticated-orcid":false,"given":"Kenda","family":"Alkwatli","sequence":"first","affiliation":[{"name":"Endocrinology Starling Physicians  Wethersfield Connecticut USA"},{"name":"Center for Quantitative Metabolic Research Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Endocrinology and Metabolism Medical Specialty Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Center for Quantitative Metabolic Research Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Quantitative Health Sciences Cleveland Clinic Research, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arshiya","family":"Mariam\u2010Smith","sequence":"additional","affiliation":[{"name":"Center for Quantitative Metabolic Research Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Quantitative Health Sciences Cleveland Clinic Research, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nerea","family":"Lopetegui","sequence":"additional","affiliation":[{"name":"Center for Quantitative Metabolic Research Cleveland Clinic  Cleveland Ohio USA"},{"name":"Comprehensive Cancer Center The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio L.","family":"Griebeler","sequence":"additional","affiliation":[{"name":"Center for Quantitative Metabolic Research Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Endocrinology and Metabolism Medical Specialty Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartolome","family":"Burguera","sequence":"additional","affiliation":[{"name":"Center for Quantitative Metabolic Research Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Endocrinology and Metabolism Medical Specialty Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3897-4551","authenticated-orcid":false,"given":"Kevin M.","family":"Pantalone","sequence":"additional","affiliation":[{"name":"Center for Quantitative Metabolic Research Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Endocrinology and Metabolism Medical Specialty Institute, Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Quantitative Health Sciences Cleveland Clinic Research, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Rotroff","sequence":"additional","affiliation":[{"name":"Center for Quantitative Metabolic Research Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Endocrinology and Metabolism Medical Specialty Institute, Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Quantitative Health Sciences Cleveland Clinic Research, Cleveland Clinic  Cleveland Ohio 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