{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:51:53Z","timestamp":1777945913946,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA253302"],"award-info":[{"award-number":["R01CA253302"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA253302\u201002S1"],"award-info":[{"award-number":["R01CA253302\u201002S1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R25CA217725"],"award-info":[{"award-number":["R25CA217725"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA023074"],"award-info":[{"award-number":["P30CA023074"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Obesity is associated with the risk of several cancers, yet conventional anthropometric measures do not distinguish the contributions of different compartments of abdominal adipose tissue. This study examined the relationship between visceral (VAT) and subcutaneous (SAT) abdominal adiposity and the incidence of 13 obesity\u2010related cancers (ObRCs) in postmenopausal women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from 9950 postmenopausal participants in the Women's Health Initiative (WHI) dual\u2010energy X\u2010ray absorptiometry (DXA) cohort were analyzed. Abdominal VAT and SAT were quantified from DXA scans using validated imaging software. Fine and Gray competing\u2010risks models estimated associations with ObRC incidence over 177,295 person\u2010years of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher abdominal VAT was significantly associated with higher ObRC risk, independently of BMI, waist circumference (WC), and other confounders. Each 100\u2010cm\n                      <jats:sup>2<\/jats:sup>\n                      increase in VAT corresponded to a 32% higher risk, with a nearly twofold increase for women in the highest VAT quartile. SAT and the VAT\/SAT ratio were also significantly associated with risk, though more modestly. Findings were consistent across BMI, WC, age, and race\/ethnicity strata and in time\u2010varying models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Visceral adiposity has a strong, independent association with ObRC risk in postmenopausal women. Incorporating imaging\u2010based body composition measures may improve cancer risk stratification and guide targeted prevention strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov identifier:\u00a0NCT00000611\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT00000611\">https:\/\/clinicaltrials.gov\/study\/NCT00000611<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70168","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T13:50:20Z","timestamp":1774014620000},"page":"997-1009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>DXA<\/scp>\n                    \u2010Derived Abdominal Adiposity and Obesity\u2010Related Cancer Risk Among Postmenopausal Women in the Women's Health Initiative"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4040-4056","authenticated-orcid":false,"given":"Robert M.","family":"Blew","sequence":"first","affiliation":[{"name":"Department of Health Promotion Sciences The University of Arizona  Tucson Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5958-2015","authenticated-orcid":false,"given":"Shelby G.","family":"Ziller","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics The University of Arizona  Tucson Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew O.","family":"Odegaard","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California, Irvine  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bette J.","family":"Caan","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Division of Research  Pleasanton California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences The University of Arizona  Tucson Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise J.","family":"Roe","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics The University of Arizona  Tucson Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JoAnn E.","family":"Manson","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Rohan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley S.","family":"Felix","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, College of Public Health The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly R.","family":"Harris","sequence":"additional","affiliation":[{"name":"Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhua","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Indiana University  Bloomington Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy S.","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Family, Population and Preventive Medicine Stony Brook University Renaissance School of Medicine  Stony Brook New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer W.","family":"Bea","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences The University of Arizona  Tucson Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnz014"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv088"},{"key":"e_1_2_10_4_1","unstructured":"World Cancer Research Fund\/American Institute for Cancer Research Body Fatness and Weight Gain and the Risk of Cancer Continuous Update Project Expert Report 2018 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