{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:55:34Z","timestamp":1793134534226,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Two glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) (semaglutide and liraglutide) and one dual agonist (tirzepatide) are FDA\u2010approved for weight loss in adults with obesity without type 2 diabetes mellitus. This systematic review and network meta\u2010analysis aims to compare the efficacy of these agents against each other.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search of PubMed\/MEDLINE, Embase, Web of Science, and Cochrane Library was conducted from inception to May 2025. Phase 3 randomized controlled trials (RCTs) in adult patients (\u2265\u200918\u2009years) with at least one arm of tirzepatide, semaglutide, or liraglutide were included. A frequentist random\u2010effects network meta\u2010analysis was performed using R 4.3.3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1420 articles identified, 15 RCTs with 14,059 patients were included. All agents significantly reduced body weight compared to placebo. The largest reduction occurred with the maximum tolerated dose of tirzepatide, followed by tirzepatide 15\u2009mg and 10\u2009mg, semaglutide 2.4\u2009mg, tirzepatide 5\u2009mg, and liraglutide 3\u2009mg. Tirzepatide and semaglutide were associated with a higher risk of any adverse event compared with placebo, whereas liraglutide was not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tirzepatide, particularly at higher doses, provides the greatest weight reduction in adults without diabetes. Future studies should evaluate discontinuation, weight regain, metabolic outcomes, cost\u2010effectiveness, and patient preferences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70169","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T02:18:34Z","timestamp":1775441914000},"page":"1210-1229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Weight Loss With\n                    <scp>GLP<\/scp>\n                    \u20101 Agonists in Nondiabetic Adults: Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1002","volume":"34","author":[{"given":"Michael","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Clinical and Administrative Pharmacy University of Georgia College of Pharmacy  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-7007","authenticated-orcid":false,"given":"Pooja","family":"Gokhale","sequence":"additional","affiliation":[{"name":"Department of Clinical and Administrative Pharmacy University of Georgia College of Pharmacy  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akwasi","family":"Akosah","sequence":"additional","affiliation":[{"name":"Department of Clinical and Administrative Pharmacy University of Georgia College of Pharmacy  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3821-4595","authenticated-orcid":false,"given":"Lorenzo","family":"Villa\u2010Zapata","sequence":"additional","affiliation":[{"name":"Department of Clinical and Administrative Pharmacy University of Georgia College of Pharmacy  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"StatPearls","author":"Panuganti K. 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