{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:51:25Z","timestamp":1777945885656,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2021 SGR 00030"],"award-info":[{"award-number":["2021 SGR 00030"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007512","name":"Universitat Rovira i Virgili","doi-asserted-by":"publisher","award":["2023PMF\u2010PIPF\u201017"],"award-info":[{"award-number":["2023PMF\u2010PIPF\u201017"]}],"id":[{"id":"10.13039\/501100007512","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n This study aimed to investigate the platelet\u2010activating factor (PAF) pathway in obesity\u2010associated metabolic dysfunction\u2010associated steatotic liver disease (MASLD) by evaluating hepatic expression of the PAF receptor (\n PAFR<\/jats:italic>\n ) and circulating levels of lipoprotein\u2010associated phospholipase A2 (Lp\u2010PLA2) across different stages of disease severity.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Liver biopsies and blood samples were collected from 64 women with severe obesity undergoing bariatric surgery. Hepatic\n PAFR<\/jats:italic>\n mRNA expression was quantified by qRT\u2010PCR, and plasma Lp\u2010PLA2 concentrations were measured using ELISA. Histological evaluation of MASLD and metabolic dysfunction\u2010associated steatohepatitis (MASH) was performed according to established criteria. Associations between biochemical, histological, and molecular parameters were analyzed using appropriate statistical tests.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Hepatic\n PAFR<\/jats:italic>\n expression was significantly upregulated in MASLD, with the highest levels observed in patients with MASH.\n PAFR<\/jats:italic>\n expression correlated positively with key histological features, including steatosis, lobular inflammation, and hepatocyte ballooning. In contrast, circulating Lp\u2010PLA2 levels did not differ across MASLD stages and showed no correlation with hepatic\n PAFR<\/jats:italic>\n expression or with liver injury markers.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The PAF\u2010PAFR axis is upregulated in obesity\u2010associated MASLD and is strongly linked to inflammatory and injury\u2010related histological features, supporting PAFR as a potential therapeutic target. Conversely, plasma Lp\u2010PLA2 does not appear to be a reliable noninvasive biomarker of MASLD severity in women with obesity.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/oby.70178","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:55:20Z","timestamp":1774518920000},"page":"1056-1067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelet\u2010Activating Factor Pathway in Women With Metabolic Dysfunction\u2010Associated Steatotic Liver Disease and Obesity"],"prefix":"10.1002","volume":"34","author":[{"given":"Joan","family":"Duran\u2010Bertran","sequence":"first","affiliation":[{"name":"Servei Medicina Interna Hospital Universitari de Tarragona Joan XXIII Tarragona 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Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarida","family":"Vives","sequence":"additional","affiliation":[{"name":"Servei de Cirurgia, Hospital Sant Joan de Reus, Departament de Medicina i Cirurgia Universitat Rovira i Virgili, Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili Reus Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Par\u00eds","sequence":"additional","affiliation":[{"name":"Servei de Cirurgia, Hospital Sant Joan de Reus, Departament de Medicina i Cirurgia Universitat Rovira i Virgili, Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili Reus Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e0tima","family":"Sabench","sequence":"additional","affiliation":[{"name":"Servei de Cirurgia, Hospital Sant Joan de Reus, Departament de Medicina i Cirurgia Universitat Rovira i Virgili, Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili Reus 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