{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:01:58Z","timestamp":1781085718507,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020400","name":"Clinical and Translational Science Center, Weill Cornell Medicine","doi-asserted-by":"publisher","award":["UL1TR002384"],"award-info":[{"award-number":["UL1TR002384"]}],"id":[{"id":"10.13039\/100020400","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n This study compared\u00a0weight\u2010loss outcomes in patients prescribed tirzepatide by weight\u2010loss status and assessed results among patients transitioning from semaglutide.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective cohort study analyzed 6\u2010month weight\u2010loss outcomes in adults treated with tirzepatide between May 2022 and January 2023. Patients were classified as weight\u2010reduced if they had lost \u2265\u200910% total body weight (TBW) before starting tirzepatide. Among those who switched from therapeutic semaglutide (\u2265\u20091.7\u2009mg weekly for \u2265\u20091\u2009month), reasons for switching were categorized as non\u2010response (<\u20095% weight loss after \u2265\u20093\u2009months), plateau (\u2265\u20095% loss followed by weight stabilization), or other.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 941 charts, 293 (31.1%) met inclusion criteria (65% female; mean age 52\u2009years; mean BMI 36.15\u2009kg\/m\n 2<\/jats:sup>\n ). Weight\u2010reduced patients (\n n<\/jats:italic>\n \u2009=\u2009133) lost 7.2% TBW versus 10.3% in non\u2010weight\u2010reduced patients (\n n<\/jats:italic>\n \u2009=\u2009160;\n p<\/jats:italic>\n \u2009<\u20090.001). When analyses were stratified by type 2 diabetes (T2D) status, this difference remained significant among patients without T2D. Sixty\u2010one patients switched from semaglutide due to non\u2010response or plateau and lost 5.3% TBW. Those switching at a plateau (\n n<\/jats:italic>\n \u2009=\u200928) lost 8.1% versus 2.9% for non\u2010responders (\n n<\/jats:italic>\n \u2009=\u200933;\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Tirzepatide produced meaningful weight loss across groups but outcomes varied based on weight\u2010reduction status, T2D status, and prior response to semaglutide.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/oby.70179","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:53:00Z","timestamp":1774691580000},"page":"97-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010World Weight\u2010Loss Outcomes in Weight\u2010Reduced Patients Treated With Tirzepatide"],"prefix":"10.1002","volume":"34","author":[{"given":"Sarah R.","family":"Barenbaum","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Comprehensive Weight Control Center Weill Cornell Medicine New York New York USA"},{"name":"Weill Cornell Medical College New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Verzani","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Population Health Sciences Weill Cornell Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice S.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpana P.","family":"Shukla","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Comprehensive Weight Control Center Weill Cornell Medicine New York New York USA"},{"name":"Weill Cornell Medical College New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206038"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01200-X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.24945"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02597-w"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2416394"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-017-0262-y"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23371"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503093321001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.4.906"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.6.1526"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.70179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/oby.70179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/oby.70179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:34:27Z","timestamp":1781084067000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.70179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,28]]},"references-count":10,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/oby.70179"],"URL":"https:\/\/doi.org\/10.1002\/oby.70179","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,28]]},"assertion":[{"value":"2025-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}