{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:52:27Z","timestamp":1777945947287,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study examined the safety and efficacy of the fixed\u2010dose, extended\u2010release combination of naltrexone and bupropion (NB\u2010ER) in individuals with overweight\/obesity and mild to moderate symptoms of depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were pooled from four double\u2010blind, placebo\u2010controlled trials. Participants with baseline Inventory of Depressive Symptomatology\u2014Self\u2010Report scores \u2265\u200914 suggestive of mild or greater depressive symptoms were included (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009511). Primary outcomes were 56\u2010week percent weight loss and changes in depression, as well as safety data for psychiatric adverse events (PAEs), depressive symptom increases, and suicidal ideation. Multiple imputation was applied, and outcomes were compared in the intention\u2010to\u2010treat population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In participants with symptoms of depression, 56\u2010week weight loss was significantly greater with NB\u2010ER (5.7%\u2009\u00b1\u20090.6%) than with placebo (2.7%\u2009\u00b1\u20090.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Participants experienced clinically meaningful improvements in depression of \u22127.1\u2009\u00b1\u20090.4 with NB\u2010ER and \u22126.7\u2009\u00b1\u20090.5 with placebo, with no significant differences between the groups. NB\u2010ER and placebo did not differ in safety signals including PAE occurrence (27.5% NB\u2010ER vs. 22.1% placebo), depressive symptom increases (9.5% NB\u2010ER vs. 8.8% placebo), or suicidal ideation (1.8% NB\u2010ER vs. 2.0% placebo).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NB\u2010ER appears to be both safe and effective for weight loss when offered to patients with mild to moderate symptoms of depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70183","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:39:42Z","timestamp":1774964382000},"page":"1010-1019","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of Naltrexone\u2013Bupropion in Persons With Overweight\/Obesity and Symptoms of Depression: A Pooled Analysis"],"prefix":"10.1002","volume":"34","author":[{"given":"Jena Shaw","family":"Tronieri","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Center for Weight and Eating Disorders Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-3705","authenticated-orcid":false,"given":"Robert F.","family":"Kushner","sequence":"additional","affiliation":[{"name":"Department of Medicine Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8029-1922","authenticated-orcid":false,"given":"Caroline M.","family":"Apovian","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Center for Weight Management and Wellness  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9912-5994","authenticated-orcid":false,"given":"Angela","family":"Fitch","sequence":"additional","affiliation":[{"name":"Knownwell  Needham Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Still","sequence":"additional","affiliation":[{"name":"Geisinger Commonwealth School of Medicine  Danville Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0438-4609","authenticated-orcid":false,"given":"Thomas A.","family":"Wadden","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Center for Weight and Eating Disorders Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp14X677482"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2025.2478812"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2016.07.003"},{"key":"e_1_2_10_5_1","unstructured":"L. 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