{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:02:26Z","timestamp":1781085746612,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK120772"],"award-info":[{"award-number":["R01DK120772"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00DK098294"],"award-info":[{"award-number":["R00DK098294"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03TR003350"],"award-info":[{"award-number":["R03TR003350"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002529"],"award-info":[{"award-number":["UL1TR002529"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK134901"],"award-info":[{"award-number":["DK134901"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n Obesity, a major driver for diabetes development, is characterized by insulin and leptin resistance. We previously showed that loss of G protein\u2010coupled receptor 17 (Gpr17) in specific hypothalamic neurons and the intestine led to better energy balance and glucose metabolism. Our goal is to test whether general loss of Gpr17 enhances insulin and leptin sensitivity.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We generated germline\n Gpr17<\/jats:italic>\n knockout mice on both lean (\n Gpr17<\/jats:italic>\n \n \u2212\/\u2212<\/jats:italic>\n <\/jats:sup>\n ) and obese (\n Gpr17<\/jats:italic>\n \n \u2212\/\u2212<\/jats:italic>\n <\/jats:sup>\n ;\n ob\/ob<\/jats:italic>\n ) backgrounds and characterized their metabolic profile.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Gpr17<\/jats:italic>\n \n \u2212\/\u2212<\/jats:italic>\n <\/jats:sup>\n mice exhibited increased energy expenditure and oxygen consumption. Euglycemic\u2010hyperinsulinemic clamp studies showed enhanced insulin sensitivity in\n Gpr17<\/jats:italic>\n \n \u2212\/\u2212<\/jats:italic>\n <\/jats:sup>\n mice with increased glycogen synthesis and decreased glycolysis.\n Gpr17<\/jats:italic>\n \n \u2212\/\u2212<\/jats:italic>\n <\/jats:sup>\n ob\/ob<\/jats:italic>\n mice had increased insulin sensitivity with lower baseline serum insulin and higher response to exogenous leptin treatment with more reduction in feeding and increased pStat3 activation in hypothalamic nuclei.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n These findings highlight the inhibitory effect of Gpr17 in leptin and insulin sensitivity, suggesting its potential as a therapeutic target for obesity treatment.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/oby.70202","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:39:43Z","timestamp":1778737183000},"page":"77-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["G Protein\u2010Coupled Receptor 17 (Gpr17) Enhances Leptin and Insulin Sensitivity in Lean and Obese Mouse Models"],"prefix":"10.1002","volume":"34","author":[{"given":"Xun","family":"Sun","sequence":"first","affiliation":[{"name":"Herman B Wells Center for Pediatric Research, Department of Pediatrics Indiana University School of Medicine Indianapolis Indiana USA"},{"name":"Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine Indianapolis Indiana USA"},{"name":"Stark Neurosciences Research Institute, Indiana University School of Medicine Indianapolis Indiana 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