{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:15:09Z","timestamp":1788340509194,"version":"build-2803163510"},"reference-count":72,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01RX003981"],"award-info":[{"award-number":["I01RX003981"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK056350\u201023"],"award-info":[{"award-number":["P30DK056350\u201023"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Incretin mimetics are increasingly prescribed for the treatment of overweight and obesity, resulting not only in significant weight reduction but also co\u2010occurring improvements in cardiovascular health and quality of life. Incretin mimetic use among older adults is expected to increase as the population ages into obesity. However, older adults experience accelerated losses in skeletal muscle mass and bone mineral density, and it remains unclear how incretin mimetics affect these processes. This review outlines the age\u2010associated changes in muscle and bone and explores current evidence reporting the effects\/associations of incretin mimetics on these tissues, as well as on physical function and fragility fracture risk. We identified several incretin mimetic weight reduction trials that demonstrated significant losses in lean soft tissue (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096 studies) and\/or indices of bone (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093); however, the clinical significance of these decrements on physical function and\/or fragility fracture remains unclear. Considering a rising trend in the prescription of incretin mimetics to treat obesity in older adulthood, a more robust characterization of the impact of these medications on lean soft tissue, physical function, and fragility fracture is needed to support future clinical decision\u2010making in older adults with overweight\/obesity.\n                  <\/jats:p>","DOI":"10.1002\/oby.70203","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T04:47:46Z","timestamp":1783918066000},"page":"36-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effects of Incretin Mimetic Therapies on Muscle and Bone Health in Older Adults: A Narrative Review"],"prefix":"10.1002","volume":"34","author":[{"given":"Joseph M.","family":"Saavedra","sequence":"first","affiliation":[{"name":"Sealy Center on Aging, University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa S.","family":"Chen","sequence":"additional","affiliation":[{"name":"Section of General Internal Medicine, Department of Internal Medicine Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn N.","family":"Porter Starr","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Geriatrics and Palliative Care Duke University School of Medicine  Durham North Carolina USA"},{"name":"Geriatric Research Education and Clinical Center, Durham VA Health Care System  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Batsis","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine, School of Medicine University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Department of Nutrition, Gillings School of Global Public Health University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00266"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacadv.2025.102150"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.106"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2010.04.012"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP161365.GL"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u2010789X.2010.00740.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.18219"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2415550121"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2015.1054810"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS\u201024\u201001590"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S7004"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010021\u201001710\u20100"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2307563"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15620"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18816"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010024\u201001529\u2010z"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE\u201016\u20100603"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539\u2010014\u20100146\u2010x"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2017.10.014"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109221"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2022.04.012"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv027"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4504"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr046"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)31138\u20109"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.07.005"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328358d59b"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.10.1059"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010018\u20100062\u20109"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr010"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16419"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.afos.2025.06.003"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afae052"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41043\u2010024\u201000500\u2010y"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13395\u2010022\u201000309\u20105"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2022.101616"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040916"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.15620\/cdc:103477"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2022.03.011"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.14\u20102\u2010187"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.37765\/ajmc.2025.89778"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1431292"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102782"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001931\u2010z"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.70029"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajcnut.2025.05.022"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12888"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz140"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14090"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2028198"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14567"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2023.2930"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010019\u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