{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:44:43Z","timestamp":1782693883639,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA142543"],"award-info":[{"award-number":["P30CA142543"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP210130"],"award-info":[{"award-number":["RP210130"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluated\u00a0the association between antiobesity medications (AOM) and incident cardiovascular disease (CVD) among older women, examining this relationship within and across survivors of obesity\u2010related cancers (ORCa) and age\u2010matched cancer\u2010free populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective cohort study using SEER\u2013Medicare data from 2007 to 2015. The study included 46,552 women aged \u2265\u200965\u2009years: ORCa survivors (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923,276) and age\u2010 and index\u2010matched cancer\u2010free women (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923,276). Prediagnostic AOM prescriptions before CVD onset were examined using intent\u2010to\u2010treat (ITT) and per\u2010protocol approaches. Multivariable Cox proportional hazards models estimated hazard ratios (HR) and 95% CI for incident CVD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In ITT analyses, AOM use was associated with lower CVD incidence in the composite analytic sample (HR\u2009=\u20090.80, 95% CI: 0.71\u20130.90) and among cancer\u2010free women (HR\u2009=\u20090.70, 95% CI: 0.58\u20130.85). Among ORCa survivors, estimates suggested a similar direction but were not statistically significant. In per\u2010protocol analyses, AOM use was associated with reduced CVD risk in ORCa survivors (HR\u2009=\u20090.74, 95% CI: 0.57\u20130.94) and cancer\u2010free women (HR\u2009=\u20090.59, 95% CI: 0.45\u20130.77). These associations were more pronounced within the first 2\u2009years of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AOM use was inversely associated with incident CVD among ORCa survivors and cancer\u2010free women. Further studies of second\u2010generation AOM, particularly glucagon\u2010like peptide\u20101 receptor agonists, are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.70211","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:22:01Z","timestamp":1777954921000},"page":"1343-1353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular Disease and Obesity Medications in Older Women by Obesity\u2010Related Cancers Status:\n                    <scp>SEER<\/scp>\n                    \u2010Medicare 2007\u20132015"],"prefix":"10.1002","volume":"34","author":[{"given":"David S.","family":"Lopez","sequence":"first","affiliation":[{"name":"Peter O'Donnell School of Public Health, UT Southwestern Medical Center  Dallas Texas USA"},{"name":"Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Abdelgadir","sequence":"additional","affiliation":[{"name":"Peter O'Donnell School of Public Health, UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7637-4127","authenticated-orcid":false,"given":"Jes\u00fas Gibran","family":"Hern\u00e1ndez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Peter O'Donnell School of Public Health, UT Southwestern Medical Center  Dallas Texas USA"},{"name":"Center for Population Health Research, National Institute of Public Health  Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2312-8449","authenticated-orcid":false,"given":"Maryam R.","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of New Mexico Health Sciences Center  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4185-5294","authenticated-orcid":false,"given":"Mohanad","family":"Albayyaa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmi","family":"Nair","sequence":"additional","affiliation":[{"name":"Peter O'Donnell School of Public Health, UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Fang","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0462-0843","authenticated-orcid":false,"given":"Jaime P.","family":"Almandoz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay G.","family":"Cowell","sequence":"additional","affiliation":[{"name":"Peter O'Donnell School of Public Health, UT Southwestern Medical Center  Dallas Texas USA"},{"name":"Harold C. 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